Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Sleep patterning changes in a prenatal stress model of depression

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Maintaining Competence in Airway Management

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Minimising droplet and virus spread during and after tracheal extubation

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  3. ActiveAxADD: Toward non-parametric and orientationally invariant axon diameter distribution mapping using PGSE

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Ex vivo diffusion-weighted MRI tractography of the Göttingen minipig limbic system

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. From variance to guidance for awake tracheal intubation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Clinical depression is accompanied by changes in sleep patterning, which is controlled in a circadian fashion. It is thus desirable that animal models of depression mirror such diurnally-specific state alterations, along with other behavioral and physiological changes. We previously found several changes in behavior indicative of a depression-like phenotype in offspring of rats subjected to repeated, variable prenatal stress (PNS), including increased locomotor activity during specific periods of the circadian cycle. We, therefore, investigated whether PNS rats also exhibit alterations in sleep/wakefulness behavior around the change from light-to-dark phase. Control and PNS Sprague-Dawley rats were implanted with electrodes for continuous monitoring of electroencephalic activity used to determine behavioral state. The distribution of slow-wave sleep (SWS), rapid eye movement sleep (REMS) and wakefulness was compared for periods before and after lights were turned off, between baseline conditions and after exposure to an acute stressor. Both REMS and SWS amounts were increased in PNS rats relative to control animals in the beginning of the dark phase. REMS changes were due to an increase in REMS bout number, rather than in bout duration. During this circadian time period, we did not find any sex differences in the state changes. These results indicate that PNS affects baseline sleep patterning in both male and female rats around active-phase onset.

OriginalsprogEngelsk
TidsskriftJournal of Developmental Origins of Health and Disease
Vol/bind9
Udgave nummer1
Sider (fra-til)102-111
ISSN2040-1744
DOI
StatusUdgivet - 1 feb. 2018

ID: 51663267