Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Single- vs. double-dose gadolinium contrast in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in knee osteoarthritis: is dose reduction possible on 3-T MRI?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. New Section Editor: Chest Imaging

    Publikation: Bidrag til tidsskriftTidsskriftartikelFormidling

  2. New section editor: Abdominal and Gastrointestinal Radiology

    Publikation: Bidrag til tidsskriftTidsskriftartikelFormidling

  3. New MSK editor

    Publikation: Bidrag til tidsskriftTidsskriftartikelFormidling

  4. Grading lumbar disc degeneration: a comparison between low- and high-field MRI

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. The effects of rotation on radiological parameters in the spine

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Weight-bearing MRI of the Lumbar Spine: Spinal Stenosis and Spondylolisthesis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Weight-bearing MRI of the Lumbar Spine: Technical Aspects

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Reduction in gadolinium (Gd) contrast agents is wanted due to the uncertainty of the potential side effects.

PURPOSE: To investigate whether it is possible to reduce the contrast dose from conventional double dose to single dose when increasing the field strength from 1.5-T to 3-T for separating early cartilage degeneration from healthy cartilage, assessed by delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC).

MATERIAL AND METHODS: Nine patients with knee osteoarthritis (OA), Kellgren-Lawrence grade (KLG) 1-4, were recruited from an ongoing weight loss cohort study. dGEMRIC was performed at 3-T using single (0.1 mmoI/kg) and double (0.2 mmoI/kg) doses of intravenous (i.v.) Gd-DTPA2-. Regions of interest (ROls) were drawn around the posterior weight-bearing femoral knee cartilage in lateral and medial compartments. In five medial compartments ROIs could not be drawn due to severe degeneration of cartilage. T1-relaxation times were compared to previously published values from 1.5-T and to non-contrast values from 3-T.

RESULTS: Mean dGEMRIC T1-relaxation time in the lateral compartment was 769 ms for single dose vs. 561 ms for double dose ( P < 0.0001); and 685 ms for single dose vs. 454 ms for double dose ( P = 0.004) in the medial compartment.

CONCLUSION: We found a dose-response relationship between single and double doses of Gd-DTPA2- using 3-T in knee OA patients, similar to the findings at 1.5-T. Compared to the T1-relaxation time at 3-T without contrast (1240 ms), this further separation between OA and normal cartilage indicates that "single dose" dGEMRIC could be sufficient for cartilage health assessment at 3-T.

OriginalsprogEngelsk
TidsskriftActa Radiologica
Vol/bind60
Udgave nummer6
Sider (fra-til)749-754
Antal sider6
ISSN0284-1851
DOI
StatusUdgivet - jun. 2019

ID: 57855159