Single nucleotide polymorphisms in IL1B and the risk of acute coronary syndrome: a Danish case-cohort study

Jakob Gerhard Stegger; Erik Berg Schmidt; Anne Tjønneland; Tine Iskov Kopp; Thorkild I A Sørensen; Ulla Birgitte Vogel; Kim Overvad

doi:10.1371/journal.pone.0036829

Single nucleotide polymorphisms in IL1B and the risk of acute coronary syndrome: a Danish case-cohort study

Jakob Gerhard Stegger, Erik Berg Schmidt, Anne Tjønneland, Tine Iskov Kopp, Thorkild I A Sørensen, Ulla Birgitte Vogel, Kim Overvad

20 Citationer (Scopus)

Abstract

Interleukin-1B (IL-1B) is a key pro-inflammatory cytokine that has been associated with the development of atherosclerosis and myocardial infarction. However, the prospective associations between functional single nucleotide polymorphisms (SNPs) in IL1B and incident acute coronary syndrome (ACS) have not been thoroughly investigated. The aims of this study were to examine the associations between individual SNPs in and SNP haplotypes of the promoter region of IL1B and incident ACS in a prospective study. Furthermore, we wanted to explore potential interactions with other risk factors for ACS on an additive scale.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	7
Udgave nummer	6
Sider (fra-til)	e36829
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0036829
Status	Udgivet - 2012

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10.1371/journal.pone.0036829

Citationsformater

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title = "Single nucleotide polymorphisms in IL1B and the risk of acute coronary syndrome: a Danish case-cohort study",

abstract = "Interleukin-1B (IL-1B) is a key pro-inflammatory cytokine that has been associated with the development of atherosclerosis and myocardial infarction. However, the prospective associations between functional single nucleotide polymorphisms (SNPs) in IL1B and incident acute coronary syndrome (ACS) have not been thoroughly investigated. The aims of this study were to examine the associations between individual SNPs in and SNP haplotypes of the promoter region of IL1B and incident ACS in a prospective study. Furthermore, we wanted to explore potential interactions with other risk factors for ACS on an additive scale.",

keywords = "Acute Coronary Syndrome, Cohort Studies, Confidence Intervals, Denmark, Female, Genetic Predisposition to Disease, Haplotypes, Humans, Incidence, Interleukin-1beta, Male, Middle Aged, Polymorphism, Single Nucleotide, Proportional Hazards Models, Risk Factors",

author = "Stegger, {Jakob Gerhard} and Schmidt, {Erik Berg} and Anne Tj{\o}nneland and Kopp, {Tine Iskov} and S{\o}rensen, {Thorkild I A} and Vogel, {Ulla Birgitte} and Kim Overvad",

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TY - JOUR

T1 - Single nucleotide polymorphisms in IL1B and the risk of acute coronary syndrome

T2 - a Danish case-cohort study

AU - Stegger, Jakob Gerhard

AU - Schmidt, Erik Berg

AU - Tjønneland, Anne

AU - Kopp, Tine Iskov

AU - Sørensen, Thorkild I A

AU - Vogel, Ulla Birgitte

AU - Overvad, Kim

PY - 2012

Y1 - 2012

N2 - Interleukin-1B (IL-1B) is a key pro-inflammatory cytokine that has been associated with the development of atherosclerosis and myocardial infarction. However, the prospective associations between functional single nucleotide polymorphisms (SNPs) in IL1B and incident acute coronary syndrome (ACS) have not been thoroughly investigated. The aims of this study were to examine the associations between individual SNPs in and SNP haplotypes of the promoter region of IL1B and incident ACS in a prospective study. Furthermore, we wanted to explore potential interactions with other risk factors for ACS on an additive scale.

AB - Interleukin-1B (IL-1B) is a key pro-inflammatory cytokine that has been associated with the development of atherosclerosis and myocardial infarction. However, the prospective associations between functional single nucleotide polymorphisms (SNPs) in IL1B and incident acute coronary syndrome (ACS) have not been thoroughly investigated. The aims of this study were to examine the associations between individual SNPs in and SNP haplotypes of the promoter region of IL1B and incident ACS in a prospective study. Furthermore, we wanted to explore potential interactions with other risk factors for ACS on an additive scale.

KW - Acute Coronary Syndrome

KW - Cohort Studies

KW - Confidence Intervals

KW - Denmark

KW - Female

KW - Genetic Predisposition to Disease

KW - Haplotypes

KW - Humans

KW - Incidence

KW - Interleukin-1beta

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Proportional Hazards Models

KW - Risk Factors

U2 - 10.1371/journal.pone.0036829

DO - 10.1371/journal.pone.0036829

M3 - Journal article

C2 - 22768033

SN - 1932-6203

VL - 7

SP - e36829

JO - P L o S One

JF - P L o S One

IS - 6

ER -

Single nucleotide polymorphisms in IL1B and the risk of acute coronary syndrome: a Danish case-cohort study

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