Single dose oxazepam has no effect on acetaminophen clearance or metabolism

J Sonne; H E Poulsen; P B Andreasen

doi:10.1007/BF00614210

Single dose oxazepam has no effect on acetaminophen clearance or metabolism

J Sonne, H E Poulsen, P B Andreasen

Klinisk Farmakologisk Afdeling BFH

7 Citationer (Scopus)

Abstract

The metabolism of acetaminophen and oxazepam in humans is mainly dependent on the microsomal capacity for glucuronide conjugation. The clearance of acetaminophen and the formation of metabolites were evaluated in 7 patients before and during concomitant administration of oxazepam 30 mg. The subjects received a single 500 mg dose of acetaminophen i.v. and concentrations in plasma were measured for 360 minutes and in urine for 24 h in order to estimate the production of metabolites. The single therapeutic dose of oxazepam had no effect on the clearance of acetaminophen or on formation of its metabolites.

Originalsprog	Engelsk
Tidsskrift	European Journal of Clinical Pharmacology
Vol/bind	30
Udgave nummer	1
Sider (fra-til)	127-9
Antal sider	3
ISSN	0031-6970
DOI	https://doi.org/10.1007/BF00614210
Status	Udgivet - 1986

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10.1007/BF00614210

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title = "Single dose oxazepam has no effect on acetaminophen clearance or metabolism",

abstract = "The metabolism of acetaminophen and oxazepam in humans is mainly dependent on the microsomal capacity for glucuronide conjugation. The clearance of acetaminophen and the formation of metabolites were evaluated in 7 patients before and during concomitant administration of oxazepam 30 mg. The subjects received a single 500 mg dose of acetaminophen i.v. and concentrations in plasma were measured for 360 minutes and in urine for 24 h in order to estimate the production of metabolites. The single therapeutic dose of oxazepam had no effect on the clearance of acetaminophen or on formation of its metabolites.",

keywords = "Acetaminophen/metabolism, Adult, Aged, Biotransformation, Drug Interactions, Female, Half-Life, Humans, Kinetics, Male, Middle Aged, Oxazepam/pharmacology",

author = "J Sonne and Poulsen, {H E} and Andreasen, {P B}",

year = "1986",

doi = "10.1007/BF00614210",

language = "English",

volume = "30",

pages = "127--9",

journal = "European Journal of Clinical Pharmacology",

issn = "0031-6970",

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TY - JOUR

T1 - Single dose oxazepam has no effect on acetaminophen clearance or metabolism

AU - Sonne, J

AU - Poulsen, H E

AU - Andreasen, P B

PY - 1986

Y1 - 1986

N2 - The metabolism of acetaminophen and oxazepam in humans is mainly dependent on the microsomal capacity for glucuronide conjugation. The clearance of acetaminophen and the formation of metabolites were evaluated in 7 patients before and during concomitant administration of oxazepam 30 mg. The subjects received a single 500 mg dose of acetaminophen i.v. and concentrations in plasma were measured for 360 minutes and in urine for 24 h in order to estimate the production of metabolites. The single therapeutic dose of oxazepam had no effect on the clearance of acetaminophen or on formation of its metabolites.

AB - The metabolism of acetaminophen and oxazepam in humans is mainly dependent on the microsomal capacity for glucuronide conjugation. The clearance of acetaminophen and the formation of metabolites were evaluated in 7 patients before and during concomitant administration of oxazepam 30 mg. The subjects received a single 500 mg dose of acetaminophen i.v. and concentrations in plasma were measured for 360 minutes and in urine for 24 h in order to estimate the production of metabolites. The single therapeutic dose of oxazepam had no effect on the clearance of acetaminophen or on formation of its metabolites.

KW - Acetaminophen/metabolism

KW - Adult

KW - Aged

KW - Biotransformation

KW - Drug Interactions

KW - Female

KW - Half-Life

KW - Humans

KW - Kinetics

KW - Male

KW - Middle Aged

KW - Oxazepam/pharmacology

U2 - 10.1007/BF00614210

DO - 10.1007/BF00614210

M3 - Journal article

C2 - 3709627

SN - 0031-6970

VL - 30

SP - 127

EP - 129

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

IS - 1

ER -

Single dose oxazepam has no effect on acetaminophen clearance or metabolism

Abstract

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