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Simvastatin improves mitochondrial respiration in peripheral blood cells

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Harvard

Durhuus, JA, Hansson, S, Morville, T, Kuhlman, AB, Dohlmann, TL, Larsen, S, Helge, JW, Angleys, M, Muniesa-Vargas, A, Bundgaard, JR, Hickson, ID, Dela, F, Desler, C & Rasmussen, LJ 2020, 'Simvastatin improves mitochondrial respiration in peripheral blood cells', Scientific Reports, bind 10, nr. 1, 17012, s. 17012. https://doi.org/10.1038/s41598-020-73896-2

APA

Durhuus, J. A., Hansson, S., Morville, T., Kuhlman, A. B., Dohlmann, T. L., Larsen, S., Helge, J. W., Angleys, M., Muniesa-Vargas, A., Bundgaard, J. R., Hickson, I. D., Dela, F., Desler, C., & Rasmussen, L. J. (2020). Simvastatin improves mitochondrial respiration in peripheral blood cells. Scientific Reports, 10(1), 17012. [17012]. https://doi.org/10.1038/s41598-020-73896-2

CBE

Durhuus JA, Hansson S, Morville T, Kuhlman AB, Dohlmann TL, Larsen S, Helge JW, Angleys M, Muniesa-Vargas A, Bundgaard JR, Hickson ID, Dela F, Desler C, Rasmussen LJ. 2020. Simvastatin improves mitochondrial respiration in peripheral blood cells. Scientific Reports. 10(1):17012. https://doi.org/10.1038/s41598-020-73896-2

MLA

Vancouver

Durhuus JA, Hansson S, Morville T, Kuhlman AB, Dohlmann TL, Larsen S o.a. Simvastatin improves mitochondrial respiration in peripheral blood cells. Scientific Reports. 2020 okt 12;10(1):17012. 17012. https://doi.org/10.1038/s41598-020-73896-2

Author

Durhuus, Jon Ambæk ; Hansson, Svenja ; Morville, Thomas ; Kuhlman, Anja Birk ; Dohlmann, Tine Lovsø ; Larsen, Steen ; Helge, Jørn Wulff ; Angleys, Maria ; Muniesa-Vargas, Alba ; Bundgaard, Jens René ; Hickson, Ian David ; Dela, Flemming ; Desler, Claus ; Rasmussen, Lene Juel. / Simvastatin improves mitochondrial respiration in peripheral blood cells. I: Scientific Reports. 2020 ; Bind 10, Nr. 1. s. 17012.

Bibtex

@article{cee7b8d653a349e7832e2fb55a66e012,
title = "Simvastatin improves mitochondrial respiration in peripheral blood cells",
abstract = "Statins are prescribed to treat hypercholesterolemia and to reduce the risk of cardiovascular disease. However, statin users frequently report myalgia, which can discourage physical activity or cause patients to discontinue statin use, negating the potential benefit of the treatment. Although a proposed mechanism responsible for Statin-Associated Myopathy (SAM) suggests a correlation with impairment of mitochondrial function, the relationship is still poorly understood. Here, we provide evidence that long-term treatment of hypercholesterolemic patients with Simvastatin at a therapeutic dose significantly display increased mitochondrial respiration in peripheral blood mononuclear cells (PBMCs), and platelets compared to untreated controls. Furthermore, the amount of superoxide is higher in mitochondria in PBMCs, and platelets from Simvastatin-treated patients than in untreated controls, and the abundance of mitochondrial superoxide, but not mitochondrial respiration trends with patient-reported myalgia. Ubiquinone (also known as coenzyme Q10) has been suggested as a potential treatment for SAM; however, an 8-week course of oral ubiquinone had no impact on mitochondrial functions or the abundance of superoxide in mitochondria from PBMCs, and platelets. These results demonstrate that long-term treatment with Simvastatin increases respiration and the production of superoxide in mitochondria of PBMCs and platelets.",
author = "Durhuus, {Jon Amb{\ae}k} and Svenja Hansson and Thomas Morville and Kuhlman, {Anja Birk} and Dohlmann, {Tine Lovs{\o}} and Steen Larsen and Helge, {J{\o}rn Wulff} and Maria Angleys and Alba Muniesa-Vargas and Bundgaard, {Jens Ren{\'e}} and Hickson, {Ian David} and Flemming Dela and Claus Desler and Rasmussen, {Lene Juel}",
year = "2020",
month = oct,
day = "12",
doi = "10.1038/s41598-020-73896-2",
language = "English",
volume = "10",
pages = "17012",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Simvastatin improves mitochondrial respiration in peripheral blood cells

AU - Durhuus, Jon Ambæk

AU - Hansson, Svenja

AU - Morville, Thomas

AU - Kuhlman, Anja Birk

AU - Dohlmann, Tine Lovsø

AU - Larsen, Steen

AU - Helge, Jørn Wulff

AU - Angleys, Maria

AU - Muniesa-Vargas, Alba

AU - Bundgaard, Jens René

AU - Hickson, Ian David

AU - Dela, Flemming

AU - Desler, Claus

AU - Rasmussen, Lene Juel

PY - 2020/10/12

Y1 - 2020/10/12

N2 - Statins are prescribed to treat hypercholesterolemia and to reduce the risk of cardiovascular disease. However, statin users frequently report myalgia, which can discourage physical activity or cause patients to discontinue statin use, negating the potential benefit of the treatment. Although a proposed mechanism responsible for Statin-Associated Myopathy (SAM) suggests a correlation with impairment of mitochondrial function, the relationship is still poorly understood. Here, we provide evidence that long-term treatment of hypercholesterolemic patients with Simvastatin at a therapeutic dose significantly display increased mitochondrial respiration in peripheral blood mononuclear cells (PBMCs), and platelets compared to untreated controls. Furthermore, the amount of superoxide is higher in mitochondria in PBMCs, and platelets from Simvastatin-treated patients than in untreated controls, and the abundance of mitochondrial superoxide, but not mitochondrial respiration trends with patient-reported myalgia. Ubiquinone (also known as coenzyme Q10) has been suggested as a potential treatment for SAM; however, an 8-week course of oral ubiquinone had no impact on mitochondrial functions or the abundance of superoxide in mitochondria from PBMCs, and platelets. These results demonstrate that long-term treatment with Simvastatin increases respiration and the production of superoxide in mitochondria of PBMCs and platelets.

AB - Statins are prescribed to treat hypercholesterolemia and to reduce the risk of cardiovascular disease. However, statin users frequently report myalgia, which can discourage physical activity or cause patients to discontinue statin use, negating the potential benefit of the treatment. Although a proposed mechanism responsible for Statin-Associated Myopathy (SAM) suggests a correlation with impairment of mitochondrial function, the relationship is still poorly understood. Here, we provide evidence that long-term treatment of hypercholesterolemic patients with Simvastatin at a therapeutic dose significantly display increased mitochondrial respiration in peripheral blood mononuclear cells (PBMCs), and platelets compared to untreated controls. Furthermore, the amount of superoxide is higher in mitochondria in PBMCs, and platelets from Simvastatin-treated patients than in untreated controls, and the abundance of mitochondrial superoxide, but not mitochondrial respiration trends with patient-reported myalgia. Ubiquinone (also known as coenzyme Q10) has been suggested as a potential treatment for SAM; however, an 8-week course of oral ubiquinone had no impact on mitochondrial functions or the abundance of superoxide in mitochondria from PBMCs, and platelets. These results demonstrate that long-term treatment with Simvastatin increases respiration and the production of superoxide in mitochondria of PBMCs and platelets.

UR - http://www.scopus.com/inward/record.url?scp=85092466764&partnerID=8YFLogxK

U2 - 10.1038/s41598-020-73896-2

DO - 10.1038/s41598-020-73896-2

M3 - Journal article

C2 - 33046789

VL - 10

SP - 17012

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 17012

ER -

ID: 61114259