Simultaneous recording of the gastro-entero-pancreatic hormonal peptide response to food in man

P J Hornnes; C Kühl; J J Holst; K B Lauritsen; J F Rehfeld; T W Schwartz

doi:10.1016/0026-0495(80)90203-6

Simultaneous recording of the gastro-entero-pancreatic hormonal peptide response to food in man

P J Hornnes, C Kühl, J J Holst, K B Lauritsen, J F Rehfeld, T W Schwartz

30 Citationer (Scopus)

Abstract

The serum or plasma concentrations of gastrin, gastric inhibitory polypeptide (GIP), gut glucagon-like-immunoreactivity (gut GLI), secretin, vasoactive intestinal polypeptide (VIP), insulin, glucagon, and pancreatic polypeptide (PP) were recorded simultaneously following the ingestion of a normal, mixed meal in seven healthy, normal weight men. The concentrations of PP and gastrin increased within 10 min. Subsequently GIP, insulin, glucagon, and gut GLI increased in the order mentioned. The mean concentrations of secretin and VIP were not affected by the meal, athough transient decreases in secretion concentrations could be detected in all subjects. The concentrations of the other hormones remained elevated for 4 hr or more. Perhaps the period of observation following food stimulation of gastro-entero-pancreatic hormones should be extended.

Originalsprog	Engelsk
Tidsskrift	Metabolism: Clinical and Experimental
Vol/bind	29
Udgave nummer	8
Sider (fra-til)	777-9
Antal sider	3
ISSN	0026-0495
DOI	https://doi.org/10.1016/0026-0495(80)90203-6
Status	Udgivet - aug. 1980
Udgivet eksternt	Ja

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10.1016/0026-0495(80)90203-6

Citationsformater

@article{8067808046614259a3626e86d5a24e29,

title = "Simultaneous recording of the gastro-entero-pancreatic hormonal peptide response to food in man",

abstract = "The serum or plasma concentrations of gastrin, gastric inhibitory polypeptide (GIP), gut glucagon-like-immunoreactivity (gut GLI), secretin, vasoactive intestinal polypeptide (VIP), insulin, glucagon, and pancreatic polypeptide (PP) were recorded simultaneously following the ingestion of a normal, mixed meal in seven healthy, normal weight men. The concentrations of PP and gastrin increased within 10 min. Subsequently GIP, insulin, glucagon, and gut GLI increased in the order mentioned. The mean concentrations of secretin and VIP were not affected by the meal, athough transient decreases in secretion concentrations could be detected in all subjects. The concentrations of the other hormones remained elevated for 4 hr or more. Perhaps the period of observation following food stimulation of gastro-entero-pancreatic hormones should be extended.",

keywords = "Adult, Food, Gastric Inhibitory Polypeptide/blood, Gastrins/blood, Gastrointestinal Hormones/blood, Glucagon/blood, Glucagon-Like Peptides/blood, Humans, Insulin/blood, Kinetics, Male, Pancreatic Hormones/blood, Pancreatic Polypeptide/blood, Secretin/blood, Vasoactive Intestinal Peptide/blood",

author = "Hornnes, {P J} and C K{\"u}hl and Holst, {J J} and Lauritsen, {K B} and Rehfeld, {J F} and Schwartz, {T W}",

year = "1980",

month = aug,

doi = "10.1016/0026-0495(80)90203-6",

language = "English",

volume = "29",

pages = "777--9",

journal = "Metabolism: Clinical and Experimental",

issn = "0026-0495",

publisher = "W.B./Saunders Co",

number = "8",

}

TY - JOUR

T1 - Simultaneous recording of the gastro-entero-pancreatic hormonal peptide response to food in man

AU - Hornnes, P J

AU - Kühl, C

AU - Holst, J J

AU - Lauritsen, K B

AU - Rehfeld, J F

AU - Schwartz, T W

PY - 1980/8

Y1 - 1980/8

N2 - The serum or plasma concentrations of gastrin, gastric inhibitory polypeptide (GIP), gut glucagon-like-immunoreactivity (gut GLI), secretin, vasoactive intestinal polypeptide (VIP), insulin, glucagon, and pancreatic polypeptide (PP) were recorded simultaneously following the ingestion of a normal, mixed meal in seven healthy, normal weight men. The concentrations of PP and gastrin increased within 10 min. Subsequently GIP, insulin, glucagon, and gut GLI increased in the order mentioned. The mean concentrations of secretin and VIP were not affected by the meal, athough transient decreases in secretion concentrations could be detected in all subjects. The concentrations of the other hormones remained elevated for 4 hr or more. Perhaps the period of observation following food stimulation of gastro-entero-pancreatic hormones should be extended.

AB - The serum or plasma concentrations of gastrin, gastric inhibitory polypeptide (GIP), gut glucagon-like-immunoreactivity (gut GLI), secretin, vasoactive intestinal polypeptide (VIP), insulin, glucagon, and pancreatic polypeptide (PP) were recorded simultaneously following the ingestion of a normal, mixed meal in seven healthy, normal weight men. The concentrations of PP and gastrin increased within 10 min. Subsequently GIP, insulin, glucagon, and gut GLI increased in the order mentioned. The mean concentrations of secretin and VIP were not affected by the meal, athough transient decreases in secretion concentrations could be detected in all subjects. The concentrations of the other hormones remained elevated for 4 hr or more. Perhaps the period of observation following food stimulation of gastro-entero-pancreatic hormones should be extended.

KW - Adult

KW - Food

KW - Gastric Inhibitory Polypeptide/blood

KW - Gastrins/blood

KW - Gastrointestinal Hormones/blood

KW - Glucagon/blood

KW - Glucagon-Like Peptides/blood

KW - Humans

KW - Insulin/blood

KW - Kinetics

KW - Male

KW - Pancreatic Hormones/blood

KW - Pancreatic Polypeptide/blood

KW - Secretin/blood

KW - Vasoactive Intestinal Peptide/blood

U2 - 10.1016/0026-0495(80)90203-6

DO - 10.1016/0026-0495(80)90203-6

M3 - Journal article

C2 - 6995794

SN - 0026-0495

VL - 29

SP - 777

EP - 779

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

IS - 8

ER -

Simultaneous recording of the gastro-entero-pancreatic hormonal peptide response to food in man

Abstract

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