TY - JOUR
T1 - Significance of Subtle Diffusion Weighted Imaging Lesion Dynamics
T2 - A Comparative Analysis of Methods for Detecting Diffusion Weighted Imaging Lesion Reversal in Endovascular Stroke Treatment
AU - Skattør, Thor Håkon
AU - Bakke, Kine Mari
AU - Nome, Terje
AU - Bjørnerud, Atle
AU - Enriquez, Brian Anthony
AU - Offersen, Cecilie Mørck
AU - Digernes, Ingrid
AU - Aamodt, Anne Hege
AU - Beyer, Mona Kristiansen
N1 - © 2025 The Author(s). Stroke: Vascular and Interventional Neurology published by Wiley Periodicals LLC on behalf of American Heart Association; The Society for Vascular and Interventional Neurology.
PY - 2025/11
Y1 - 2025/11
N2 - BACKGROUND: Restrictive diffusion on magnetic resonance imaging is recognized as an early marker of ischemic brain damage, even though diffusion-weighted imaging lesion reversal (DWI-R) is well known. This study aimed to compare methodologies for detecting DWI-R, including voxel-based analysis, which captures subtle lesion dynamics, and to test their correlation with clinical outcomes.METHODS: We retrospectively analyzed magnetic resonance imaging data from 216 consecutive patients with acute ischemic stroke obtained before and after endovascular therapy. DWI-R was defined either as an increase in DWI-Alberta Stroke Program Early Computed Tomography Score, a decrease of total DWI signal volume or as partial reversal of the initial DWI lesion, irrespective of the final DWI load. Associations between 3-month poststroke modified Rankin scale score and DWI-R was assessed according to the different definitions of DWI-R using logistic binary regression.RESULTS: In patients undergoing endovascular therapy, 25% had increased DWI-Alberta Stroke Program Early Computed Tomography Score and 32% showed reduced DWI volume. Both measures were strongly associated with favorable outcomes (modified Rankin Scale score ≤2) with odds ratios of 4.90 and 5.60, respectively (95% CIs: 1.66-14.46 and 2.09-14.98). Voxel-based analysis revealed DWI-R of ≥20% of the initial lesion in 64.5% of cases. Even with an overall increase of lesion volume due to progression elsewhere, ≥20% reversal of initial lesion was associated with a significantly improved outcome compared with <20% reversal, odds ratio 2.22 (95% CIs: 1.05-4.70).CONCLUSION: DWI-R was common in patients treated with endovascular therapy and linked to favorable outcomes. Subtle lesion dynamics detected only by the voxel-based analysis also conferred significant clinical benefits, supporting DWI-R as a continuum rather than a binary measure as "present" or "absent."
AB - BACKGROUND: Restrictive diffusion on magnetic resonance imaging is recognized as an early marker of ischemic brain damage, even though diffusion-weighted imaging lesion reversal (DWI-R) is well known. This study aimed to compare methodologies for detecting DWI-R, including voxel-based analysis, which captures subtle lesion dynamics, and to test their correlation with clinical outcomes.METHODS: We retrospectively analyzed magnetic resonance imaging data from 216 consecutive patients with acute ischemic stroke obtained before and after endovascular therapy. DWI-R was defined either as an increase in DWI-Alberta Stroke Program Early Computed Tomography Score, a decrease of total DWI signal volume or as partial reversal of the initial DWI lesion, irrespective of the final DWI load. Associations between 3-month poststroke modified Rankin scale score and DWI-R was assessed according to the different definitions of DWI-R using logistic binary regression.RESULTS: In patients undergoing endovascular therapy, 25% had increased DWI-Alberta Stroke Program Early Computed Tomography Score and 32% showed reduced DWI volume. Both measures were strongly associated with favorable outcomes (modified Rankin Scale score ≤2) with odds ratios of 4.90 and 5.60, respectively (95% CIs: 1.66-14.46 and 2.09-14.98). Voxel-based analysis revealed DWI-R of ≥20% of the initial lesion in 64.5% of cases. Even with an overall increase of lesion volume due to progression elsewhere, ≥20% reversal of initial lesion was associated with a significantly improved outcome compared with <20% reversal, odds ratio 2.22 (95% CIs: 1.05-4.70).CONCLUSION: DWI-R was common in patients treated with endovascular therapy and linked to favorable outcomes. Subtle lesion dynamics detected only by the voxel-based analysis also conferred significant clinical benefits, supporting DWI-R as a continuum rather than a binary measure as "present" or "absent."
U2 - 10.1161/SVIN.125.001835
DO - 10.1161/SVIN.125.001835
M3 - Journal article
C2 - 41608702
SN - 2694-5746
VL - 5
SP - e001835
JO - Stroke (Hoboken, N.J.)
JF - Stroke (Hoboken, N.J.)
IS - 6
ER -