Significance of K(ATP) channels, L-type Ca²⁺ channels and CYP450-4A enzymes in oxygen sensing in mouse cremaster muscle arterioles in vivo

Thuc Anh Ngo, Mads Achen Riemann, Niels-Henrik Holstein-Rathlou, Christian Torp-Pedersen, Lars Jørn Jensen

    18 Citationer (Scopus)

    Abstract

    ATP-sensitive K⁺ channels (KATP channels), NO, prostaglandins, 20-HETE and L-type Ca²⁺ channels have all been suggested to be involved in oxygen sensing in skeletal muscle arterioles, but the role of the individual mechanisms remain controversial. We aimed to establish the importance of these mechanisms for oxygen sensing in arterioles in an in vivo model of metabolically active skeletal muscle. For this purpose we utilized the exteriorized cremaster muscle of anesthetized mice, in which the cremaster muscle was exposed to controlled perturbation of tissue PO₂.
    OriginalsprogEngelsk
    TidsskriftB M C Physiology
    Vol/bind13
    Sider (fra-til)8
    ISSN1472-6793
    DOI
    StatusUdgivet - 2013

    Fingeraftryk

    Dyk ned i forskningsemnerne om 'Significance of K(ATP) channels, L-type Ca²⁺ channels and CYP450-4A enzymes in oxygen sensing in mouse cremaster muscle arterioles in vivo'. Sammen danner de et unikt fingeraftryk.

    Citationsformater