@article{337543878bbb4f6c97546572540c8628,
title = "Short telomere length is associated with NOTCH1/SF3B1/TP53 aberrations and poor outcome in newly diagnosed chronic lymphocytic leukemia patients",
abstract = "Most previous studies on telomere length (TL) in chronic lymphocytic leukemia (CLL) are based on referral cohorts including a high proportion of aggressive cases. Here, the impact of TL was analyzed in a population-based cohort of newly diagnosed CLL (n = 265) and in relation to other prognostic markers. Short telomeres were particularly associated with high-risk genetic markers, such as NOTCH1, SF3B1, or TP53 aberrations, and predicted a short time to treatment (TTT) and overall survival (OS) (both P ",
keywords = "Aged, Disease-Free Survival, Female, Follow-Up Studies, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Male, Middle Aged, Mutation, Phosphoproteins, Predictive Value of Tests, Receptor, Notch1, Retrospective Studies, Ribonucleoprotein, U2 Small Nuclear, Survival Rate, Telomere, Tumor Markers, Biological, Tumor Suppressor Protein p53",
author = "Larry Mansouri and Pawel Grabowski and Sofie Degerman and Ulrika Svenson and Rebeqa Gunnarsson and Nicola Cahill and Smedby, {Karin Ekstr{\"o}m} and Christian Geisler and Gunnar Juliusson and G{\"o}ran Roos and Richard Rosenquist",
note = "Copyright {\textcopyright} 2013 Wiley Periodicals, Inc.",
year = "2013",
month = aug,
doi = "10.1002/ajh.23466",
language = "English",
volume = "88",
pages = "647--51",
journal = "American Journal of Hematology",
issn = "0361-8609",
publisher = "John Wiley and Sons Inc.",
number = "8",
}