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Region Hovedstaden - en del af Københavns Universitetshospital
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Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  • V P Garcia
  • J D Mattos
  • J Mentzinger
  • P E C Leite
  • H N M Rocha
  • M O Campos
  • M P Rocha
  • D E Mansur
  • N H Secher
  • A C L Nóbrega
  • I A Fernandes
  • N G Rocha
Vis graf over relationer

In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 years) were exposed to 5-min normoxia (21% O2) and 10-min hyperoxia trials (100% O2). During hyperoxia, intercellular adhesion molecules (ICAM-1) (hyperoxia: 4.16±0.85 vs normoxia: 3.51±0.84 ng/mL, P=0.04) and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) (hyperoxia: 8.40±3.84 vs normoxia: 5.73±2.15 pg/mL, P=0.04) increased, whereas matrix metalloproteinase (MMP-9) activity (hyperoxia: 0.53±0.11 vs normoxia: 0.68±0.18 A.U., P=0.03) decreased compared to the normoxia trial. We concluded that even short exposure to 100% oxygen may affect endothelial activation and vascular remodeling.

OriginalsprogEngelsk
Artikelnummere12110
TidsskriftBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
Vol/bind55
Sider (fra-til)e12110
ISSN0100-879X
DOI
StatusUdgivet - 2022

ID: 78649361