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Region Hovedstaden - en del af Københavns Universitetshospital
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Short erythropoietin-derived peptide enhances memory, improves long-term potentiation, and counteracts amyloid beta-induced pathology

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  1. Striking reduction in neurons and glial cells in anterior thalamic nuclei of older patients with Down syndrome

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  2. The total number of myelinated nerve fibers is reduced in corpus callosum in brains from patients with Alzheimer's disease

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  3. The effect of long-term treatment with coenzyme Q10 on nucleic acid modifications by oxidation in children with Down syndrome

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  4. EEG correlates of visual short-term memory in older age vary with adult lifespan cognitive development

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  1. Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients

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  2. Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression

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  3. Towards automatic glaucoma assessment: An Encoder-decoder CNN for Retinal Layer Segmentation in Rodent OCT images

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  4. Gut and immune effects of bioactive milk factors in preterm pigs exposed to prenatal inflammation

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  5. Bovine Milk Oligosaccharides with Sialyllactose Improves Cognition in Preterm Pigs

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Vis graf over relationer

Neurodegenerative disorders such as Alzheimer's disease (AD) are characterized by the irreversible neuronal loss and memory impairment, and current treatments are merely symptomatic. Erythropoietin (EPO) has been shown to possess neurotrophic, neuroprotective, anti-inflammatory, and memory-enhancing effects, which could be therapeutically beneficial in the different aspects of AD. However, the hematopoietic effect of EPO has hampered its potential as a neuroprotective and procognitive agent. In this study, we characterized a novel small peptide, NL100, derived from a conserved C-helix region of EPO. NL100 was shown to bind to the EPO receptor, induce neuritogenesis, and protect hippocampal neurons from oxidative- and Aβ25-35-induced neurodegeneration in vitro. Importantly, long-term NL100 treatment did not induce hematopoiesis, overcoming this challenge associated with EPO. Memory-enhancing effects were demonstrated after NL100 treatment in social recognition test for short-term memory, in both healthy rats and rats challenged centrally with Aβ25-35 peptide, and in the Morris water maze test for spatial memory. Moreover, NL100 was shown to reverse Aβ25-35-induced hippocampal degeneration and gliosis as well as pilocarpine-induced suppression of long-term potentiation in rats. In conclusion, NL100 is a novel EPO-derived nonhematopoietic peptide with neuroprotective and memory-enhancing effects and could therefore be a potential candidate for the development of new treatments for neurodegenerative disorders and dementia.

OriginalsprogEngelsk
TidsskriftNeurobiology of Aging
Vol/bind81
Sider (fra-til)88-101
Antal sider14
ISSN0197-4580
DOI
StatusUdgivet - sep. 2019

Bibliografisk note

Copyright © 2019 Elsevier Inc. All rights reserved.

ID: 59292981