Short- and long-term effects of endurance training in patients with mitochondrial myopathy

T D Jeppesen, M Dunø, M Schwartz, T Krag, J Rafiq, F Wibrand, J Vissing

Abstract

BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations.

METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations.

RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle.

CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Neurology
Vol/bind16
Udgave nummer12
Sider (fra-til)1336-9
Antal sider4
ISSN1351-5101
DOI
StatusUdgivet - dec. 2009

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