Short- and long-term effects of endurance training in patients with mitochondrial myopathy

T D Jeppesen; M Dunø; M Schwartz; T Krag; J Rafiq; F Wibrand; J Vissing

doi:10.1111/j.1468-1331.2009.02660.x

Short- and long-term effects of endurance training in patients with mitochondrial myopathy

T D Jeppesen, M Dunø, M Schwartz, T Krag, J Rafiq, F Wibrand, J Vissing

39 Citationer (Scopus)

Abstract

BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations.

METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations.

RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle.

CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.

Originalsprog	Engelsk
Tidsskrift	European Journal of Neurology
Vol/bind	16
Udgave nummer	12
Sider (fra-til)	1336-9
Antal sider	4
ISSN	1351-5101
DOI	https://doi.org/10.1111/j.1468-1331.2009.02660.x
Status	Udgivet - dec. 2009

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10.1111/j.1468-1331.2009.02660.x

Citationsformater

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abstract = "BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations.METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations.RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle.CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.",

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author = "Jeppesen, {T D} and M Dun{\o} and M Schwartz and T Krag and J Rafiq and F Wibrand and J Vissing",

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T1 - Short- and long-term effects of endurance training in patients with mitochondrial myopathy

AU - Jeppesen, T D

AU - Dunø, M

AU - Schwartz, M

AU - Krag, T

AU - Rafiq, J

AU - Wibrand, F

AU - Vissing, J

PY - 2009/12

Y1 - 2009/12

N2 - BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations.METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations.RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle.CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.

AB - BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations.METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations.RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle.CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.

KW - Exercise Therapy/methods

KW - Exercise Tolerance/physiology

KW - Humans

KW - Mitochondrial Myopathies/metabolism

KW - Muscle, Skeletal/metabolism

KW - Time

U2 - 10.1111/j.1468-1331.2009.02660.x

DO - 10.1111/j.1468-1331.2009.02660.x

M3 - Journal article

C2 - 19486129

SN - 1351-5101

VL - 16

SP - 1336

EP - 1339

JO - European Journal of Neurology

JF - European Journal of Neurology

IS - 12

ER -

Short- and long-term effects of endurance training in patients with mitochondrial myopathy

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