Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

SHARP: enabling generation of real-world evidence on a pan-European scale to improve the lives of individuals with severe asthma

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Characteristics and impact of exercise-induced laryngeal obstruction: an international perspective

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Collaborative tuberculosis/HIV activities in the European Region

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Severe outcomes of COVID-19 among patients with COPD and asthma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Direct effects of mast cell proteases, tryptase and chymase, on bronchial epithelial integrity proteins and anti-viral responses

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Mast cell tryptase enhances wound healing by promoting migration in human bronchial epithelial cells

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Agreement Between Transcutaneous Monitoring and Arterial Blood Gases During COPD Exacerbation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Treating severe asthma: targeting the IL-5 pathway

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

Real-world evidence is important to help unravel unanswered problems in severe asthma and is valuable to better understand the patient experience and common clinical practice. The Severe Heterogeneous Asthma Registry, Patient-centred (SHARP) Clinical Research Collaboration is created as a network of national registries and severe asthma centres that work together to perform registry based real-world research and clinical studies on a pan-European scale. Such collaboration requires a new, innovative design to overcome the many issues that arise with large-scale data collection across national borders. SHARP has developed a platform that offers a federated analysis approach where national registry data are transformed and integrated into a common data model (CDM). The CDM then allows a local analysis of de-identified patient data and subsequent aggregate (meta-)analysis. To facilitate an easily accessible way to set up new registries, SHARP enables new registries to take part in a central database, based on already proven technology. Next to being economical, this linkage ensures data from different SHARP central members to be comparable. Technological advancements lead to an ever-expanding rate of patient data that will be collected; with the collective effort of the pan-European severe asthma research community SHARP hopes to ensure that they are well equipped to enter a new era of medical research, with the ultimate goal to positively impact the lives of patients with severe asthma.

OriginalsprogEngelsk
TidsskriftERJ Open Research
Vol/bind7
Udgave nummer2
ISSN2312-0541
DOI
StatusUdgivet - apr. 2021

ID: 65948198