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Region Hovedstaden - en del af Københavns Universitetshospital
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Sharing and reuse of individual participant data from clinical trials: principles and recommendations

Publikation: Bidrag til tidsskriftTidsskriftartikel

DOI

  • Christian Ohmann
  • Rita Banzi
  • Steve Canham
  • Serena Battaglia
  • Mihaela Matei
  • Christopher Ariyo
  • Lauren Becnel
  • Barbara Bierer
  • Sarion Bowers
  • Luca Clivio
  • Monica Dias
  • Christiane Druml
  • Hélène Faure
  • Martin Fenner
  • Jose Galvez
  • Davina Ghersi
  • Christian Gluud
  • Trish Groves
  • Paul Houston
  • Ghassan Karam
  • Dipak Kalra
  • Rachel L Knowles
  • Karmela Krleža-Jerić
  • Christine Kubiak
  • Wolfgang Kuchinke
  • Rebecca Kush
  • Ari Lukkarinen
  • Pedro Silverio Marques
  • Andrew Newbigging
  • Jennifer O'Callaghan
  • Philippe Ravaud
  • Irene Schlünder
  • Daniel Shanahan
  • Helmut Sitter
  • Dylan Spalding
  • Catrin Tudur-Smith
  • Peter van Reusel
  • Evert-Ben van Veen
  • Gerben Rienk Visser
  • Julia Wilson
  • Jacques Demotes-Mainard
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OBJECTIVES: We examined major issues associated with sharing of individual clinical trial data and developed a consensus document on providing access to individual participant data from clinical trials, using a broad interdisciplinary approach.

DESIGN AND METHODS: This was a consensus-building process among the members of a multistakeholder task force, involving a wide range of experts (researchers, patient representatives, methodologists, information technology experts, and representatives from funders, infrastructures and standards development organisations). An independent facilitator supported the process using the nominal group technique. The consensus was reached in a series of three workshops held over 1 year, supported by exchange of documents and teleconferences within focused subgroups when needed. This work was set within the Horizon 2020-funded project CORBEL (Coordinated Research Infrastructures Building Enduring Life-science Services) and coordinated by the European Clinical Research Infrastructure Network. Thus, the focus was on non-commercial trials and the perspective mainly European.

OUTCOME: We developed principles and practical recommendations on how to share data from clinical trials.

RESULTS: The task force reached consensus on 10 principles and 50 recommendations, representing the fundamental requirements of any framework used for the sharing of clinical trials data. The document covers the following main areas: making data sharing a reality (eg, cultural change, academic incentives, funding), consent for data sharing, protection of trial participants (eg, de-identification), data standards, rights, types and management of access (eg, data request and access models), data management and repositories, discoverability, and metadata.

CONCLUSIONS: The adoption of the recommendations in this document would help to promote and support data sharing and reuse among researchers, adequately inform trial participants and protect their rights, and provide effective and efficient systems for preparing, storing and accessing data. The recommendations now need to be implemented and tested in practice. Further work needs to be done to integrate these proposals with those from other geographical areas and other academic domains.

OriginalsprogEngelsk
TidsskriftBMJ Open
Vol/bind7
Tidsskriftsnummer12
Sider (fra-til)e018647
ISSN2044-6055
DOI
StatusUdgivet - 14 dec. 2017

ID: 52188255