Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Shared heritability and functional enrichment across six solid cancers

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

Jiang, X, Finucane, HK, Schumacher, FR, Schmit, SL, Tyrer, JP, Han, Y, Michailidou, K, Lesseur, C, Kuchenbaecker, KB, Dennis, J, Conti, DV, Casey, G, Gaudet, MM, Huyghe, JR, Albanes, D, Aldrich, MC, Andrew, AS, Andrulis, IL, Anton-Culver, H, Antoniou, AC, Antonenkova, NN, Arnold, SM, Aronson, KJ, Arun, BK, Bandera, EV, Barkardottir, RB, Barnes, DR, Batra, J, Beckmann, MW, Benitez, J, Benlloch, S, Berchuck, A, Berndt, SI, Bickeböller, H, Bien, SA, Blomqvist, C, Boccia, S, Bogdanova, NV, Bojesen, SE, Bolla, MK, Brauch, H, Brenner, H, Brenton, JD, Brook, MN, Brunet, J, Brunnström, H, Buchanan, DD, Burwinkel, B, Butzow, R, Cadoni, G, Caldés, T, Caligo, MA, Campbell, I, Campbell, PT, Cancel-Tassin, G, Cannon-Albright, L, Campa, D, Caporaso, N, Carvalho, AL, Chan, AT, Chang-Claude, J, Chanock, SJ, Chen, C, Christiani, DC, Claes, KBM, Claessens, F, Clements, J, Collée, JM, Correa, MC, Couch, FJ, Cox, A, Cunningham, JM, Cybulski, C, Czene, K, Daly, MB, deFazio, A, Devilee, P, Diez, O, Gago-Dominguez, M, Donovan, JL, Dörk, T, Duell, EJ, Dunning, AM, Dwek, M, Eccles, DM, Edlund, CK, Edwards, DRV, Ellberg, C, Evans, DG, Fasching, PA, Ferris, RL, Liloglou, T, Figueiredo, JC, Fletcher, O, Fortner, RT, Fostira, F, Franceschi, S, Friedman, E, Gallinger, SJ, Ganz, PA, Garber, J, García-Sáenz, JA, Gayther, SA, Giles, GG, Godwin, AK, Goldberg, MS, Goldgar, DE, Goode, EL, Goodman, MT, Goodman, G, Grankvist, K, Greene, MH, Gronberg, H, Gronwald, J, Guénel, P, Håkansson, N, Hall, P, Hamann, U, Hamdy, FC, Hamilton, RJ, Hampe, J, Haugen, A, Heitz, F, Herrero, R, Hillemanns, P, Hoffmeister, M, Høgdall, E, Hong, Y-C, Hopper, JL, Houlston, R, Hulick, PJ, Hunter, DJ, Huntsman, DG, Idos, G, Imyanitov, EN, Ingles, SA, Isaacs, C, Jakubowska, A, James, P, Jenkins, MA, Johansson, M, Johansson, M, John, EM, Joshi, AD, Kaneva, R, Karlan, BY, Kelemen, LE, Kühl, T, Khaw, K-T, Khusnutdinova, E, Kibel, AS, Kiemeney, LA, Kim, J, Kjaer, SK, Knight, JA, Kogevinas, M, Kote-Jarai, Z, Koutros, S, Kristensen, VN, Kupryjanczyk, J, Lacko, M, Lam, S, Lambrechts, D, Landi, MT, Lazarus, P, Le, ND, Lee, E, Lejbkowicz, F, Lenz, H-J, Leslie, G, Lessel, D, Lester, J, Levine, DA, Li, L, Li, CI, Lindblom, A, Lindor, NM, Liu, G, Loupakis, F, Lubiński, J, Maehle, L, Maier, C, Mannermaa, A, Marchand, LL, Margolin, S, May, T, McGuffog, L, Meindl, A, Middha, P, Miller, A, Milne, RL, MacInnis, RJ, Modugno, F, Montagna, M, Moreno, V, Moysich, KB, Mucci, L, Muir, K, Mulligan, AM, Nathanson, KL, Neal, DE, Ness, AR, Neuhausen, SL, Nevanlinna, H, Newcomb, PA, Newcomb, LF, Nielsen, FC, Nikitina-Zake, L, Nordestgaard, BG, Nussbaum, RL, Offit, K, Olah, E, Olama, AAA, Olopade, OI, Olshan, AF, Olsson, H, Osorio, A, Pandha, H, Park, JY, Pashayan, N, Parsons, MT, Pejovic, T, Penney, KL, Peters, WHM, Phelan, CM, Phipps, AI, Plaseska-Karanfilska, D, Pring, M, Prokofyeva, D, Radice, P, Stefansson, K, Ramus, SJ, Raskin, L, Rennert, G, Rennert, HS, van Rensburg, EJ, Riggan, MJ, Risch, HA, Risch, A, Roobol, MJ, Rosenstein, BS, Rossing, MA, De Ruyck, K, Saloustros, E, Sandler, DP, Sawyer, EJ, Schabath, MB, Schleutker, J, Schmidt, MK, Setiawan, VW, Shen, H, Siegel, EM, Sieh, W, Singer, CF, Slattery, ML, Sorensen, KD, Southey, MC, Spurdle, AB, Stanford, JL, Stevens, VL, Stintzing, S, Stone, J, Sundfeldt, K, Sutphen, R, Swerdlow, AJ, Tajara, EH, Tangen, CM, Tardon, A, Taylor, JA, Teare, MD, Teixeira, MR, Terry, MB, Terry, KL, Thibodeau, SN, Thomassen, M, Bjørge, L, Tischkowitz, M, Toland, AE, Torres, D, Townsend, PA, Travis, RC, Tung, N, Tworoger, SS, Ulrich, CM, Usmani, N, Vachon, CM, Van Nieuwenhuysen, E, Vega, A, Aguado-Barrera, ME, Wang, Q, Webb, PM, Weinberg, CR, Weinstein, S, Weissler, MC, Weitzel, JN, West, CML, White, E, Whittemore, AS, Wichmann, H-E, Wiklund, F, Winqvist, R, Wolk, A, Woll, P, Woods, M, Wu, AH, Wu, X, Yannoukakos, D, Zheng, W, Zienolddiny, S, Ziogas, A, Zorn, KK, Lane, JM, Saxena, R, Thomas, D, Hung, RJ, Diergaarde, B, McKay, J, Peters, U, Hsu, L, García-Closas, M, Eeles, RA, Chenevix-Trench, G, Brennan, PJ, Haiman, CA, Simard, J, Easton, DF, Gruber, SB, Pharoah, PDP, Price, AL, Pasaniuc, B, Amos, CI, Kraft, P & Lindström, S 2019, 'Shared heritability and functional enrichment across six solid cancers' Nature Communications, bind 10, nr. 1, 431, s. 431. https://doi.org/10.1038/s41467-018-08054-4

APA

Jiang, X., Finucane, H. K., Schumacher, F. R., Schmit, S. L., Tyrer, J. P., Han, Y., ... Lindström, S. (2019). Shared heritability and functional enrichment across six solid cancers. Nature Communications, 10(1), 431. [431]. https://doi.org/10.1038/s41467-018-08054-4

CBE

Jiang X, Finucane HK, Schumacher FR, Schmit SL, Tyrer JP, Han Y, Michailidou K, Lesseur C, Kuchenbaecker KB, Dennis J, Conti DV, Casey G, Gaudet MM, Huyghe JR, Albanes D, Aldrich MC, Andrew AS, Andrulis IL, Anton-Culver H, Antoniou AC, Antonenkova NN, Arnold SM, Aronson KJ, Arun BK, Bandera EV, Barkardottir RB, Barnes DR, Batra J, Beckmann MW, Benitez J, Benlloch S, Berchuck A, Berndt SI, Bickeböller H, Bien SA, Blomqvist C, Boccia S, Bogdanova NV, Bojesen SE, Bolla MK, Brauch H, Brenner H, Brenton JD, Brook MN, Brunet J, Brunnström H, Buchanan DD, Burwinkel B, Butzow R, Cadoni G, Caldés T, Caligo MA, Campbell I, Campbell PT, Cancel-Tassin G, Cannon-Albright L, Campa D, Caporaso N, Carvalho AL, Chan AT, Chang-Claude J, Chanock SJ, Chen C, Christiani DC, Claes KBM, Claessens F, Clements J, Collée JM, Correa MC, Couch FJ, Cox A, Cunningham JM, Cybulski C, Czene K, Daly MB, deFazio A, Devilee P, Diez O, Gago-Dominguez M, Donovan JL, Dörk T, Duell EJ, Dunning AM, Dwek M, Eccles DM, Edlund CK, Edwards DRV, Ellberg C, Evans DG, Fasching PA, Ferris RL, Liloglou T, Figueiredo JC, Fletcher O, Fortner RT, Fostira F, Franceschi S, Friedman E, Gallinger SJ, Ganz PA, Garber J, García-Sáenz JA, Gayther SA, Giles GG, Godwin AK, Goldberg MS, Goldgar DE, Goode EL, Goodman MT, Goodman G, Grankvist K, Greene MH, Gronberg H, Gronwald J, Guénel P, Håkansson N, Hall P, Hamann U, Hamdy FC, Hamilton RJ, Hampe J, Haugen A, Heitz F, Herrero R, Hillemanns P, Hoffmeister M, Høgdall E, Hong Y-C, Hopper JL, Houlston R, Hulick PJ, Hunter DJ, Huntsman DG, Idos G, Imyanitov EN, Ingles SA, Isaacs C, Jakubowska A, James P, Jenkins MA, Johansson M, Johansson M, John EM, Joshi AD, Kaneva R, Karlan BY, Kelemen LE, Kühl T, Khaw K-T, Khusnutdinova E, Kibel AS, Kiemeney LA, Kim J, Kjaer SK, Knight JA, Kogevinas M, Kote-Jarai Z, Koutros S, Kristensen VN, Kupryjanczyk J, Lacko M, Lam S, Lambrechts D, Landi MT, Lazarus P, Le ND, Lee E, Lejbkowicz F, Lenz H-J, Leslie G, Lessel D, Lester J, Levine DA, Li L, Li CI, Lindblom A, Lindor NM, Liu G, Loupakis F, Lubiński J, Maehle L, Maier C, Mannermaa A, Marchand LL, Margolin S, May T, McGuffog L, Meindl A, Middha P, Miller A, Milne RL, MacInnis RJ, Modugno F, Montagna M, Moreno V, Moysich KB, Mucci L, Muir K, Mulligan AM, Nathanson KL, Neal DE, Ness AR, Neuhausen SL, Nevanlinna H, Newcomb PA, Newcomb LF, Nielsen FC, Nikitina-Zake L, Nordestgaard BG, Nussbaum RL, Offit K, Olah E, Olama AAA, Olopade OI, Olshan AF, Olsson H, Osorio A, Pandha H, Park JY, Pashayan N, Parsons MT, Pejovic T, Penney KL, Peters WHM, Phelan CM, Phipps AI, Plaseska-Karanfilska D, Pring M, Prokofyeva D, Radice P, Stefansson K, Ramus SJ, Raskin L, Rennert G, Rennert HS, van Rensburg EJ, Riggan MJ, Risch HA, Risch A, Roobol MJ, Rosenstein BS, Rossing MA, De Ruyck K, Saloustros E, Sandler DP, Sawyer EJ, Schabath MB, Schleutker J, Schmidt MK, Setiawan VW, Shen H, Siegel EM, Sieh W, Singer CF, Slattery ML, Sorensen KD, Southey MC, Spurdle AB, Stanford JL, Stevens VL, Stintzing S, Stone J, Sundfeldt K, Sutphen R, Swerdlow AJ, Tajara EH, Tangen CM, Tardon A, Taylor JA, Teare MD, Teixeira MR, Terry MB, Terry KL, Thibodeau SN, Thomassen M, Bjørge L, Tischkowitz M, Toland AE, Torres D, Townsend PA, Travis RC, Tung N, Tworoger SS, Ulrich CM, Usmani N, Vachon CM, Van Nieuwenhuysen E, Vega A, Aguado-Barrera ME, Wang Q, Webb PM, Weinberg CR, Weinstein S, Weissler MC, Weitzel JN, West CML, White E, Whittemore AS, Wichmann H-E, Wiklund F, Winqvist R, Wolk A, Woll P, Woods M, Wu AH, Wu X, Yannoukakos D, Zheng W, Zienolddiny S, Ziogas A, Zorn KK, Lane JM, Saxena R, Thomas D, Hung RJ, Diergaarde B, McKay J, Peters U, Hsu L, García-Closas M, Eeles RA, Chenevix-Trench G, Brennan PJ, Haiman CA, Simard J, Easton DF, Gruber SB, Pharoah PDP, Price AL, Pasaniuc B, Amos CI, Kraft P, Lindström S. 2019. Shared heritability and functional enrichment across six solid cancers. Nature Communications. 10(1):431. https://doi.org/10.1038/s41467-018-08054-4

MLA

Vancouver

Jiang X, Finucane HK, Schumacher FR, Schmit SL, Tyrer JP, Han Y o.a. Shared heritability and functional enrichment across six solid cancers. Nature Communications. 2019 dec 1;10(1):431. 431. https://doi.org/10.1038/s41467-018-08054-4

Author

Jiang, Xia ; Finucane, Hilary K ; Schumacher, Fredrick R ; Schmit, Stephanie L ; Tyrer, Jonathan P ; Han, Younghun ; Michailidou, Kyriaki ; Lesseur, Corina ; Kuchenbaecker, Karoline B ; Dennis, Joe ; Conti, David V ; Casey, Graham ; Gaudet, Mia M ; Huyghe, Jeroen R ; Albanes, Demetrius ; Aldrich, Melinda C ; Andrew, Angeline S ; Andrulis, Irene L ; Anton-Culver, Hoda ; Antoniou, Antonis C ; Antonenkova, Natalia N ; Arnold, Susanne M ; Aronson, Kristan J ; Arun, Banu K ; Bandera, Elisa V ; Barkardottir, Rosa B ; Barnes, Daniel R ; Batra, Jyotsna ; Beckmann, Matthias W ; Benitez, Javier ; Benlloch, Sara ; Berchuck, Andrew ; Berndt, Sonja I ; Bickeböller, Heike ; Bien, Stephanie A ; Blomqvist, Carl ; Boccia, Stefania ; Bogdanova, Natalia V ; Bojesen, Stig E ; Bolla, Manjeet K ; Brauch, Hiltrud ; Brenner, Hermann ; Brenton, James D ; Brook, Mark N ; Brunet, Joan ; Brunnström, Hans ; Buchanan, Daniel D ; Burwinkel, Barbara ; Butzow, Ralf ; Cadoni, Gabriella ; Caldés, Trinidad ; Caligo, Maria A ; Campbell, Ian ; Campbell, Peter T ; Cancel-Tassin, Géraldine ; Cannon-Albright, Lisa ; Campa, Daniele ; Caporaso, Neil ; Carvalho, André L ; Chan, Andrew T ; Chang-Claude, Jenny ; Chanock, Stephen J ; Chen, Chu ; Christiani, David C ; Claes, Kathleen B M ; Claessens, Frank ; Clements, Judith ; Collée, J Margriet ; Correa, Marcia Cruz ; Couch, Fergus J ; Cox, Angela ; Cunningham, Julie M ; Cybulski, Cezary ; Czene, Kamila ; Daly, Mary B ; deFazio, Anna ; Devilee, Peter ; Diez, Orland ; Gago-Dominguez, Manuela ; Donovan, Jenny L ; Dörk, Thilo ; Duell, Eric J ; Dunning, Alison M ; Dwek, Miriam ; Eccles, Diana M ; Edlund, Christopher K ; Edwards, Digna R Velez ; Ellberg, Carolina ; Evans, D Gareth ; Fasching, Peter A ; Ferris, Robert L ; Liloglou, Triantafillos ; Figueiredo, Jane C ; Fletcher, Olivia ; Fortner, Renée T ; Fostira, Florentia ; Franceschi, Silvia ; Friedman, Eitan ; Gallinger, Steven J ; Ganz, Patricia A ; Garber, Judy ; García-Sáenz, José A ; Gayther, Simon A ; Giles, Graham G ; Godwin, Andrew K ; Goldberg, Mark S ; Goldgar, David E ; Goode, Ellen L ; Goodman, Marc T ; Goodman, Gary ; Grankvist, Kjell ; Greene, Mark H ; Gronberg, Henrik ; Gronwald, Jacek ; Guénel, Pascal ; Håkansson, Niclas ; Hall, Per ; Hamann, Ute ; Hamdy, Freddie C ; Hamilton, Robert J ; Hampe, Jochen ; Haugen, Aage ; Heitz, Florian ; Herrero, Rolando ; Hillemanns, Peter ; Hoffmeister, Michael ; Høgdall, Estrid ; Hong, Yun-Chul ; Hopper, John L ; Houlston, Richard ; Hulick, Peter J ; Hunter, David J ; Huntsman, David G ; Idos, Gregory ; Imyanitov, Evgeny N ; Ingles, Sue Ann ; Isaacs, Claudine ; Jakubowska, Anna ; James, Paul ; Jenkins, Mark A ; Johansson, Mattias ; Johansson, Mikael ; John, Esther M ; Joshi, Amit D ; Kaneva, Radka ; Karlan, Beth Y ; Kelemen, Linda E ; Kühl, Tabea ; Khaw, Kay-Tee ; Khusnutdinova, Elza ; Kibel, Adam S ; Kiemeney, Lambertus A ; Kim, Jeri ; Kjaer, Susanne K ; Knight, Julia A ; Kogevinas, Manolis ; Kote-Jarai, Zsofia ; Koutros, Stella ; Kristensen, Vessela N ; Kupryjanczyk, Jolanta ; Lacko, Martin ; Lam, Stephan ; Lambrechts, Diether ; Landi, Maria Teresa ; Lazarus, Philip ; Le, Nhu D ; Lee, Eunjung ; Lejbkowicz, Flavio ; Lenz, Heinz-Josef ; Leslie, Goska ; Lessel, Davor ; Lester, Jenny ; Levine, Douglas A ; Li, Li ; Li, Christopher I ; Lindblom, Annika ; Lindor, Noralane M ; Liu, Geoffrey ; Loupakis, Fotios ; Lubiński, Jan ; Maehle, Lovise ; Maier, Christiane ; Mannermaa, Arto ; Marchand, Loic Le ; Margolin, Sara ; May, Taymaa ; McGuffog, Lesley ; Meindl, Alfons ; Middha, Pooja ; Miller, Austin ; Milne, Roger L ; MacInnis, Robert J ; Modugno, Francesmary ; Montagna, Marco ; Moreno, Victor ; Moysich, Kirsten B ; Mucci, Lorelei ; Muir, Kenneth ; Mulligan, Anna Marie ; Nathanson, Katherine L ; Neal, David E ; Ness, Andrew R ; Neuhausen, Susan L ; Nevanlinna, Heli ; Newcomb, Polly A ; Newcomb, Lisa F ; Nielsen, Finn Cilius ; Nikitina-Zake, Liene ; Nordestgaard, Børge G ; Nussbaum, Robert L ; Offit, Kenneth ; Olah, Edith ; Olama, Ali Amin Al ; Olopade, Olufunmilayo I ; Olshan, Andrew F ; Olsson, Håkan ; Osorio, Ana ; Pandha, Hardev ; Park, Jong Y ; Pashayan, Nora ; Parsons, Michael T ; Pejovic, Tanja ; Penney, Kathryn L ; Peters, Wilbert H M ; Phelan, Catherine M ; Phipps, Amanda I ; Plaseska-Karanfilska, Dijana ; Pring, Miranda ; Prokofyeva, Darya ; Radice, Paolo ; Stefansson, Kari ; Ramus, Susan J ; Raskin, Leon ; Rennert, Gad ; Rennert, Hedy S ; van Rensburg, Elizabeth J ; Riggan, Marjorie J ; Risch, Harvey A ; Risch, Angela ; Roobol, Monique J ; Rosenstein, Barry S ; Rossing, Mary Anne ; De Ruyck, Kim ; Saloustros, Emmanouil ; Sandler, Dale P ; Sawyer, Elinor J ; Schabath, Matthew B ; Schleutker, Johanna ; Schmidt, Marjanka K ; Setiawan, V Wendy ; Shen, Hongbing ; Siegel, Erin M ; Sieh, Weiva ; Singer, Christian F ; Slattery, Martha L ; Sorensen, Karina Dalsgaard ; Southey, Melissa C ; Spurdle, Amanda B ; Stanford, Janet L ; Stevens, Victoria L ; Stintzing, Sebastian ; Stone, Jennifer ; Sundfeldt, Karin ; Sutphen, Rebecca ; Swerdlow, Anthony J ; Tajara, Eloiza H ; Tangen, Catherine M ; Tardon, Adonina ; Taylor, Jack A ; Teare, M Dawn ; Teixeira, Manuel R ; Terry, Mary Beth ; Terry, Kathryn L ; Thibodeau, Stephen N ; Thomassen, Mads ; Bjørge, Line ; Tischkowitz, Marc ; Toland, Amanda E ; Torres, Diana ; Townsend, Paul A ; Travis, Ruth C ; Tung, Nadine ; Tworoger, Shelley S ; Ulrich, Cornelia M ; Usmani, Nawaid ; Vachon, Celine M ; Van Nieuwenhuysen, Els ; Vega, Ana ; Aguado-Barrera, Miguel Elías ; Wang, Qin ; Webb, Penelope M ; Weinberg, Clarice R ; Weinstein, Stephanie ; Weissler, Mark C ; Weitzel, Jeffrey N ; West, Catharine M L ; White, Emily ; Whittemore, Alice S ; Wichmann, H-Erich ; Wiklund, Fredrik ; Winqvist, Robert ; Wolk, Alicja ; Woll, Penella ; Woods, Michael ; Wu, Anna H ; Wu, Xifeng ; Yannoukakos, Drakoulis ; Zheng, Wei ; Zienolddiny, Shanbeh ; Ziogas, Argyrios ; Zorn, Kristin K ; Lane, Jacqueline M ; Saxena, Richa ; Thomas, Duncan ; Hung, Rayjean J ; Diergaarde, Brenda ; McKay, James ; Peters, Ulrike ; Hsu, Li ; García-Closas, Montserrat ; Eeles, Rosalind A ; Chenevix-Trench, Georgia ; Brennan, Paul J ; Haiman, Christopher A ; Simard, Jacques ; Easton, Douglas F ; Gruber, Stephen B ; Pharoah, Paul D P ; Price, Alkes L ; Pasaniuc, Bogdan ; Amos, Christopher I ; Kraft, Peter ; Lindström, Sara. / Shared heritability and functional enrichment across six solid cancers. I: Nature Communications. 2019 ; Bind 10, Nr. 1. s. 431.

Bibtex

@article{f03af7d508d94b869044a855f6f47074,
title = "Shared heritability and functional enrichment across six solid cancers",
abstract = "Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.",
keywords = "Breast Neoplasms/diagnosis, Case-Control Studies, Colorectal Neoplasms/diagnosis, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Head and Neck Neoplasms/diagnosis, Humans, Inheritance Patterns, Lung Neoplasms/diagnosis, Male, Mental Disorders/ethnology, Neoplasm Proteins/genetics, Ovarian Neoplasms/diagnosis, Phenotype, Polymorphism, Single Nucleotide, Prostatic Neoplasms/diagnosis, Smoking/ethnology",
author = "Xia Jiang and Finucane, {Hilary K} and Schumacher, {Fredrick R} and Schmit, {Stephanie L} and Tyrer, {Jonathan P} and Younghun Han and Kyriaki Michailidou and Corina Lesseur and Kuchenbaecker, {Karoline B} and Joe Dennis and Conti, {David V} and Graham Casey and Gaudet, {Mia M} and Huyghe, {Jeroen R} and Demetrius Albanes and Aldrich, {Melinda C} and Andrew, {Angeline S} and Andrulis, {Irene L} and Hoda Anton-Culver and Antoniou, {Antonis C} and Antonenkova, {Natalia N} and Arnold, {Susanne M} and Aronson, {Kristan J} and Arun, {Banu K} and Bandera, {Elisa V} and Barkardottir, {Rosa B} and Barnes, {Daniel R} and Jyotsna Batra and Beckmann, {Matthias W} and Javier Benitez and Sara Benlloch and Andrew Berchuck and Berndt, {Sonja I} and Heike Bickeb{\"o}ller and Bien, {Stephanie A} and Carl Blomqvist and Stefania Boccia and Bogdanova, {Natalia V} and Bojesen, {Stig E} and Bolla, {Manjeet K} and Hiltrud Brauch and Hermann Brenner and Brenton, {James D} and Brook, {Mark N} and Joan Brunet and Hans Brunnstr{\"o}m and Buchanan, {Daniel D} and Barbara Burwinkel and Ralf Butzow and Gabriella Cadoni and Trinidad Cald{\'e}s and Caligo, {Maria A} and Ian Campbell and Campbell, {Peter T} and G{\'e}raldine Cancel-Tassin and Lisa Cannon-Albright and Daniele Campa and Neil Caporaso and Carvalho, {Andr{\'e} L} and Chan, {Andrew T} and Jenny Chang-Claude and Chanock, {Stephen J} and Chu Chen and Christiani, {David C} and Claes, {Kathleen B M} and Frank Claessens and Judith Clements and Coll{\'e}e, {J Margriet} and Correa, {Marcia Cruz} and Couch, {Fergus J} and Angela Cox and Cunningham, {Julie M} and Cezary Cybulski and Kamila Czene and Daly, {Mary B} and Anna deFazio and Peter Devilee and Orland Diez and Manuela Gago-Dominguez and Donovan, {Jenny L} and Thilo D{\"o}rk and Duell, {Eric J} and Dunning, {Alison M} and Miriam Dwek and Eccles, {Diana M} and Edlund, {Christopher K} and Edwards, {Digna R Velez} and Carolina Ellberg and Evans, {D Gareth} and Fasching, {Peter A} and Ferris, {Robert L} and Triantafillos Liloglou and Figueiredo, {Jane C} and Olivia Fletcher and Fortner, {Ren{\'e}e T} and Florentia Fostira and Silvia Franceschi and Eitan Friedman and Gallinger, {Steven J} and Ganz, {Patricia A} and Judy Garber and Garc{\'i}a-S{\'a}enz, {Jos{\'e} A} and Gayther, {Simon A} and Giles, {Graham G} and Godwin, {Andrew K} and Goldberg, {Mark S} and Goldgar, {David E} and Goode, {Ellen L} and Goodman, {Marc T} and Gary Goodman and Kjell Grankvist and Greene, {Mark H} and Henrik Gronberg and Jacek Gronwald and Pascal Gu{\'e}nel and Niclas H{\aa}kansson and Per Hall and Ute Hamann and Hamdy, {Freddie C} and Hamilton, {Robert J} and Jochen Hampe and Aage Haugen and Florian Heitz and Rolando Herrero and Peter Hillemanns and Michael Hoffmeister and Estrid H{\o}gdall and Yun-Chul Hong and Hopper, {John L} and Richard Houlston and Hulick, {Peter J} and Hunter, {David J} and Huntsman, {David G} and Gregory Idos and Imyanitov, {Evgeny N} and Ingles, {Sue Ann} and Claudine Isaacs and Anna Jakubowska and Paul James and Jenkins, {Mark A} and Mattias Johansson and Mikael Johansson and John, {Esther M} and Joshi, {Amit D} and Radka Kaneva and Karlan, {Beth Y} and Kelemen, {Linda E} and Tabea K{\"u}hl and Kay-Tee Khaw and Elza Khusnutdinova and Kibel, {Adam S} and Kiemeney, {Lambertus A} and Jeri Kim and Kjaer, {Susanne K} and Knight, {Julia A} and Manolis Kogevinas and Zsofia Kote-Jarai and Stella Koutros and Kristensen, {Vessela N} and Jolanta Kupryjanczyk and Martin Lacko and Stephan Lam and Diether Lambrechts and Landi, {Maria Teresa} and Philip Lazarus and Le, {Nhu D} and Eunjung Lee and Flavio Lejbkowicz and Heinz-Josef Lenz and Goska Leslie and Davor Lessel and Jenny Lester and Levine, {Douglas A} and Li Li and Li, {Christopher I} and Annika Lindblom and Lindor, {Noralane M} and Geoffrey Liu and Fotios Loupakis and Jan Lubiński and Lovise Maehle and Christiane Maier and Arto Mannermaa and Marchand, {Loic Le} and Sara Margolin and Taymaa May and Lesley McGuffog and Alfons Meindl and Pooja Middha and Austin Miller and Milne, {Roger L} and MacInnis, {Robert J} and Francesmary Modugno and Marco Montagna and Victor Moreno and Moysich, {Kirsten B} and Lorelei Mucci and Kenneth Muir and Mulligan, {Anna Marie} and Nathanson, {Katherine L} and Neal, {David E} and Ness, {Andrew R} and Neuhausen, {Susan L} and Heli Nevanlinna and Newcomb, {Polly A} and Newcomb, {Lisa F} and Nielsen, {Finn Cilius} and Liene Nikitina-Zake and Nordestgaard, {B{\o}rge G} and Nussbaum, {Robert L} and Kenneth Offit and Edith Olah and Olama, {Ali Amin Al} and Olopade, {Olufunmilayo I} and Olshan, {Andrew F} and H{\aa}kan Olsson and Ana Osorio and Hardev Pandha and Park, {Jong Y} and Nora Pashayan and Parsons, {Michael T} and Tanja Pejovic and Penney, {Kathryn L} and Peters, {Wilbert H M} and Phelan, {Catherine M} and Phipps, {Amanda I} and Dijana Plaseska-Karanfilska and Miranda Pring and Darya Prokofyeva and Paolo Radice and Kari Stefansson and Ramus, {Susan J} and Leon Raskin and Gad Rennert and Rennert, {Hedy S} and {van Rensburg}, {Elizabeth J} and Riggan, {Marjorie J} and Risch, {Harvey A} and Angela Risch and Roobol, {Monique J} and Rosenstein, {Barry S} and Rossing, {Mary Anne} and {De Ruyck}, Kim and Emmanouil Saloustros and Sandler, {Dale P} and Sawyer, {Elinor J} and Schabath, {Matthew B} and Johanna Schleutker and Schmidt, {Marjanka K} and Setiawan, {V Wendy} and Hongbing Shen and Siegel, {Erin M} and Weiva Sieh and Singer, {Christian F} and Slattery, {Martha L} and Sorensen, {Karina Dalsgaard} and Southey, {Melissa C} and Spurdle, {Amanda B} and Stanford, {Janet L} and Stevens, {Victoria L} and Sebastian Stintzing and Jennifer Stone and Karin Sundfeldt and Rebecca Sutphen and Swerdlow, {Anthony J} and Tajara, {Eloiza H} and Tangen, {Catherine M} and Adonina Tardon and Taylor, {Jack A} and Teare, {M Dawn} and Teixeira, {Manuel R} and Terry, {Mary Beth} and Terry, {Kathryn L} and Thibodeau, {Stephen N} and Mads Thomassen and Line Bj{\o}rge and Marc Tischkowitz and Toland, {Amanda E} and Diana Torres and Townsend, {Paul A} and Travis, {Ruth C} and Nadine Tung and Tworoger, {Shelley S} and Ulrich, {Cornelia M} and Nawaid Usmani and Vachon, {Celine M} and {Van Nieuwenhuysen}, Els and Ana Vega and Aguado-Barrera, {Miguel El{\'i}as} and Qin Wang and Webb, {Penelope M} and Weinberg, {Clarice R} and Stephanie Weinstein and Weissler, {Mark C} and Weitzel, {Jeffrey N} and West, {Catharine M L} and Emily White and Whittemore, {Alice S} and H-Erich Wichmann and Fredrik Wiklund and Robert Winqvist and Alicja Wolk and Penella Woll and Michael Woods and Wu, {Anna H} and Xifeng Wu and Drakoulis Yannoukakos and Wei Zheng and Shanbeh Zienolddiny and Argyrios Ziogas and Zorn, {Kristin K} and Lane, {Jacqueline M} and Richa Saxena and Duncan Thomas and Hung, {Rayjean J} and Brenda Diergaarde and James McKay and Ulrike Peters and Li Hsu and Montserrat Garc{\'i}a-Closas and Eeles, {Rosalind A} and Georgia Chenevix-Trench and Brennan, {Paul J} and Haiman, {Christopher A} and Jacques Simard and Easton, {Douglas F} and Gruber, {Stephen B} and Pharoah, {Paul D P} and Price, {Alkes L} and Bogdan Pasaniuc and Amos, {Christopher I} and Peter Kraft and Sara Lindstr{\"o}m",
year = "2019",
month = "12",
day = "1",
doi = "10.1038/s41467-018-08054-4",
language = "English",
volume = "10",
pages = "431",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Shared heritability and functional enrichment across six solid cancers

AU - Jiang, Xia

AU - Finucane, Hilary K

AU - Schumacher, Fredrick R

AU - Schmit, Stephanie L

AU - Tyrer, Jonathan P

AU - Han, Younghun

AU - Michailidou, Kyriaki

AU - Lesseur, Corina

AU - Kuchenbaecker, Karoline B

AU - Dennis, Joe

AU - Conti, David V

AU - Casey, Graham

AU - Gaudet, Mia M

AU - Huyghe, Jeroen R

AU - Albanes, Demetrius

AU - Aldrich, Melinda C

AU - Andrew, Angeline S

AU - Andrulis, Irene L

AU - Anton-Culver, Hoda

AU - Antoniou, Antonis C

AU - Antonenkova, Natalia N

AU - Arnold, Susanne M

AU - Aronson, Kristan J

AU - Arun, Banu K

AU - Bandera, Elisa V

AU - Barkardottir, Rosa B

AU - Barnes, Daniel R

AU - Batra, Jyotsna

AU - Beckmann, Matthias W

AU - Benitez, Javier

AU - Benlloch, Sara

AU - Berchuck, Andrew

AU - Berndt, Sonja I

AU - Bickeböller, Heike

AU - Bien, Stephanie A

AU - Blomqvist, Carl

AU - Boccia, Stefania

AU - Bogdanova, Natalia V

AU - Bojesen, Stig E

AU - Bolla, Manjeet K

AU - Brauch, Hiltrud

AU - Brenner, Hermann

AU - Brenton, James D

AU - Brook, Mark N

AU - Brunet, Joan

AU - Brunnström, Hans

AU - Buchanan, Daniel D

AU - Burwinkel, Barbara

AU - Butzow, Ralf

AU - Cadoni, Gabriella

AU - Caldés, Trinidad

AU - Caligo, Maria A

AU - Campbell, Ian

AU - Campbell, Peter T

AU - Cancel-Tassin, Géraldine

AU - Cannon-Albright, Lisa

AU - Campa, Daniele

AU - Caporaso, Neil

AU - Carvalho, André L

AU - Chan, Andrew T

AU - Chang-Claude, Jenny

AU - Chanock, Stephen J

AU - Chen, Chu

AU - Christiani, David C

AU - Claes, Kathleen B M

AU - Claessens, Frank

AU - Clements, Judith

AU - Collée, J Margriet

AU - Correa, Marcia Cruz

AU - Couch, Fergus J

AU - Cox, Angela

AU - Cunningham, Julie M

AU - Cybulski, Cezary

AU - Czene, Kamila

AU - Daly, Mary B

AU - deFazio, Anna

AU - Devilee, Peter

AU - Diez, Orland

AU - Gago-Dominguez, Manuela

AU - Donovan, Jenny L

AU - Dörk, Thilo

AU - Duell, Eric J

AU - Dunning, Alison M

AU - Dwek, Miriam

AU - Eccles, Diana M

AU - Edlund, Christopher K

AU - Edwards, Digna R Velez

AU - Ellberg, Carolina

AU - Evans, D Gareth

AU - Fasching, Peter A

AU - Ferris, Robert L

AU - Liloglou, Triantafillos

AU - Figueiredo, Jane C

AU - Fletcher, Olivia

AU - Fortner, Renée T

AU - Fostira, Florentia

AU - Franceschi, Silvia

AU - Friedman, Eitan

AU - Gallinger, Steven J

AU - Ganz, Patricia A

AU - Garber, Judy

AU - García-Sáenz, José A

AU - Gayther, Simon A

AU - Giles, Graham G

AU - Godwin, Andrew K

AU - Goldberg, Mark S

AU - Goldgar, David E

AU - Goode, Ellen L

AU - Goodman, Marc T

AU - Goodman, Gary

AU - Grankvist, Kjell

AU - Greene, Mark H

AU - Gronberg, Henrik

AU - Gronwald, Jacek

AU - Guénel, Pascal

AU - Håkansson, Niclas

AU - Hall, Per

AU - Hamann, Ute

AU - Hamdy, Freddie C

AU - Hamilton, Robert J

AU - Hampe, Jochen

AU - Haugen, Aage

AU - Heitz, Florian

AU - Herrero, Rolando

AU - Hillemanns, Peter

AU - Hoffmeister, Michael

AU - Høgdall, Estrid

AU - Hong, Yun-Chul

AU - Hopper, John L

AU - Houlston, Richard

AU - Hulick, Peter J

AU - Hunter, David J

AU - Huntsman, David G

AU - Idos, Gregory

AU - Imyanitov, Evgeny N

AU - Ingles, Sue Ann

AU - Isaacs, Claudine

AU - Jakubowska, Anna

AU - James, Paul

AU - Jenkins, Mark A

AU - Johansson, Mattias

AU - Johansson, Mikael

AU - John, Esther M

AU - Joshi, Amit D

AU - Kaneva, Radka

AU - Karlan, Beth Y

AU - Kelemen, Linda E

AU - Kühl, Tabea

AU - Khaw, Kay-Tee

AU - Khusnutdinova, Elza

AU - Kibel, Adam S

AU - Kiemeney, Lambertus A

AU - Kim, Jeri

AU - Kjaer, Susanne K

AU - Knight, Julia A

AU - Kogevinas, Manolis

AU - Kote-Jarai, Zsofia

AU - Koutros, Stella

AU - Kristensen, Vessela N

AU - Kupryjanczyk, Jolanta

AU - Lacko, Martin

AU - Lam, Stephan

AU - Lambrechts, Diether

AU - Landi, Maria Teresa

AU - Lazarus, Philip

AU - Le, Nhu D

AU - Lee, Eunjung

AU - Lejbkowicz, Flavio

AU - Lenz, Heinz-Josef

AU - Leslie, Goska

AU - Lessel, Davor

AU - Lester, Jenny

AU - Levine, Douglas A

AU - Li, Li

AU - Li, Christopher I

AU - Lindblom, Annika

AU - Lindor, Noralane M

AU - Liu, Geoffrey

AU - Loupakis, Fotios

AU - Lubiński, Jan

AU - Maehle, Lovise

AU - Maier, Christiane

AU - Mannermaa, Arto

AU - Marchand, Loic Le

AU - Margolin, Sara

AU - May, Taymaa

AU - McGuffog, Lesley

AU - Meindl, Alfons

AU - Middha, Pooja

AU - Miller, Austin

AU - Milne, Roger L

AU - MacInnis, Robert J

AU - Modugno, Francesmary

AU - Montagna, Marco

AU - Moreno, Victor

AU - Moysich, Kirsten B

AU - Mucci, Lorelei

AU - Muir, Kenneth

AU - Mulligan, Anna Marie

AU - Nathanson, Katherine L

AU - Neal, David E

AU - Ness, Andrew R

AU - Neuhausen, Susan L

AU - Nevanlinna, Heli

AU - Newcomb, Polly A

AU - Newcomb, Lisa F

AU - Nielsen, Finn Cilius

AU - Nikitina-Zake, Liene

AU - Nordestgaard, Børge G

AU - Nussbaum, Robert L

AU - Offit, Kenneth

AU - Olah, Edith

AU - Olama, Ali Amin Al

AU - Olopade, Olufunmilayo I

AU - Olshan, Andrew F

AU - Olsson, Håkan

AU - Osorio, Ana

AU - Pandha, Hardev

AU - Park, Jong Y

AU - Pashayan, Nora

AU - Parsons, Michael T

AU - Pejovic, Tanja

AU - Penney, Kathryn L

AU - Peters, Wilbert H M

AU - Phelan, Catherine M

AU - Phipps, Amanda I

AU - Plaseska-Karanfilska, Dijana

AU - Pring, Miranda

AU - Prokofyeva, Darya

AU - Radice, Paolo

AU - Stefansson, Kari

AU - Ramus, Susan J

AU - Raskin, Leon

AU - Rennert, Gad

AU - Rennert, Hedy S

AU - van Rensburg, Elizabeth J

AU - Riggan, Marjorie J

AU - Risch, Harvey A

AU - Risch, Angela

AU - Roobol, Monique J

AU - Rosenstein, Barry S

AU - Rossing, Mary Anne

AU - De Ruyck, Kim

AU - Saloustros, Emmanouil

AU - Sandler, Dale P

AU - Sawyer, Elinor J

AU - Schabath, Matthew B

AU - Schleutker, Johanna

AU - Schmidt, Marjanka K

AU - Setiawan, V Wendy

AU - Shen, Hongbing

AU - Siegel, Erin M

AU - Sieh, Weiva

AU - Singer, Christian F

AU - Slattery, Martha L

AU - Sorensen, Karina Dalsgaard

AU - Southey, Melissa C

AU - Spurdle, Amanda B

AU - Stanford, Janet L

AU - Stevens, Victoria L

AU - Stintzing, Sebastian

AU - Stone, Jennifer

AU - Sundfeldt, Karin

AU - Sutphen, Rebecca

AU - Swerdlow, Anthony J

AU - Tajara, Eloiza H

AU - Tangen, Catherine M

AU - Tardon, Adonina

AU - Taylor, Jack A

AU - Teare, M Dawn

AU - Teixeira, Manuel R

AU - Terry, Mary Beth

AU - Terry, Kathryn L

AU - Thibodeau, Stephen N

AU - Thomassen, Mads

AU - Bjørge, Line

AU - Tischkowitz, Marc

AU - Toland, Amanda E

AU - Torres, Diana

AU - Townsend, Paul A

AU - Travis, Ruth C

AU - Tung, Nadine

AU - Tworoger, Shelley S

AU - Ulrich, Cornelia M

AU - Usmani, Nawaid

AU - Vachon, Celine M

AU - Van Nieuwenhuysen, Els

AU - Vega, Ana

AU - Aguado-Barrera, Miguel Elías

AU - Wang, Qin

AU - Webb, Penelope M

AU - Weinberg, Clarice R

AU - Weinstein, Stephanie

AU - Weissler, Mark C

AU - Weitzel, Jeffrey N

AU - West, Catharine M L

AU - White, Emily

AU - Whittemore, Alice S

AU - Wichmann, H-Erich

AU - Wiklund, Fredrik

AU - Winqvist, Robert

AU - Wolk, Alicja

AU - Woll, Penella

AU - Woods, Michael

AU - Wu, Anna H

AU - Wu, Xifeng

AU - Yannoukakos, Drakoulis

AU - Zheng, Wei

AU - Zienolddiny, Shanbeh

AU - Ziogas, Argyrios

AU - Zorn, Kristin K

AU - Lane, Jacqueline M

AU - Saxena, Richa

AU - Thomas, Duncan

AU - Hung, Rayjean J

AU - Diergaarde, Brenda

AU - McKay, James

AU - Peters, Ulrike

AU - Hsu, Li

AU - García-Closas, Montserrat

AU - Eeles, Rosalind A

AU - Chenevix-Trench, Georgia

AU - Brennan, Paul J

AU - Haiman, Christopher A

AU - Simard, Jacques

AU - Easton, Douglas F

AU - Gruber, Stephen B

AU - Pharoah, Paul D P

AU - Price, Alkes L

AU - Pasaniuc, Bogdan

AU - Amos, Christopher I

AU - Kraft, Peter

AU - Lindström, Sara

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.

AB - Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.

KW - Breast Neoplasms/diagnosis

KW - Case-Control Studies

KW - Colorectal Neoplasms/diagnosis

KW - European Continental Ancestry Group

KW - Female

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Head and Neck Neoplasms/diagnosis

KW - Humans

KW - Inheritance Patterns

KW - Lung Neoplasms/diagnosis

KW - Male

KW - Mental Disorders/ethnology

KW - Neoplasm Proteins/genetics

KW - Ovarian Neoplasms/diagnosis

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - Prostatic Neoplasms/diagnosis

KW - Smoking/ethnology

UR - http://www.scopus.com/inward/record.url?scp=85060528251&partnerID=8YFLogxK

U2 - 10.1038/s41467-018-08054-4

DO - 10.1038/s41467-018-08054-4

M3 - Journal article

VL - 10

SP - 431

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 431

ER -

ID: 56626231