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Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium

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@article{5ac78400b3894f989c38ab1060490af5,
title = "Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium",
abstract = "OBJECTIVES: This study investigates differences between women and men in heart failure (HF) risk and mortality.BACKGROUND: Sex differences in HF epidemiology are insufficiently understood.METHODS: In 78,657 individuals (median 49.5 years of age; age range 24.1 to 98.7 years; 51.7{\%} women) from community-based European studies (FINRISK, DanMONICA, Moli-sani, Northern Sweden) of the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium, the association between incident HF and mortality, the relationship of cardiovascular risk factors, prevalent cardiovascular diseases, biomarkers (C-reactive protein [CRP]; N-terminal pro-B-type natriuretic peptide [NT-proBNP]) with incident HF, and their attributable risks were tested in women vs. men.RESULTS: Over a median follow-up of 12.7 years, fewer HF cases were observed in women (n = 2,399 [5.9{\%}]) than in men (n = 2,771 [7.3{\%}]). HF incidence increased markedly after 60 years of age, initially with a more rapid increase in men, whereas incidence in women exceeded that of men after 85 years of age. HF onset substantially increased mortality risk in both sexes. Multivariable-adjusted Cox models showed the following sex differences for the association with incident HF: systolic blood pressure hazard ratio (HR) according to SD in women of 1.09 (95{\%} confidence interval [CI]: 1.05 to 1.14) versus HR of 1.19 (95{\%} CI: 1.14 to 1.24) in men; heart rate HR of 0.98 (95{\%} CI: 0.93 to 1.03) in women versus HR of 1.09 (95{\%} CI: 1.04 to 1.13) in men; CRP HR of 1.10 (95{\%} CI: 1.00 to 1.20) in women versus HR of 1.32 (95{\%} CI: 1.24 to 1.41) in men; and NT-proBNP HR of 1.54 (95{\%} CI: 1.37 to 1.74) in women versus HR of 1.89 (95{\%} CI: 1.75 to 2.05) in men. Population-attributable risk of all risk factors combined was 59.0{\%} in women and 62.9{\%} in men.CONCLUSIONS: Women had a lower risk for HF than men. Sex differences were seen for systolic blood pressure, heart rate, CRP, and NT-proBNP, with a lower HF risk in women.",
author = "Christina Magnussen and Niiranen, {Teemu J} and Ojeda, {Francisco M} and Francesco Gianfagna and Stefan Blankenberg and Erkki Vartiainen and Susana Sans and Gerard Pasterkamp and Maria Hughes and Simona Costanzo and Donati, {Maria Benedetta} and Pekka Jousilahti and Allan Linneberg and Tarja Palosaari and {de Gaetano}, Giovanni and Martin Bobak and {den Ruijter}, {Hester M} and Torben J{\o}rgensen and Stefan S{\"o}derberg and Kari Kuulasmaa and Tanja Zeller and Licia Iacoviello and Veikko Salomaa and Schnabel, {Renate B} and {BiomarCaRE Consortium}",
note = "Copyright {\circledC} 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = "3",
doi = "10.1016/j.jchf.2018.08.008",
language = "English",
volume = "7",
pages = "204--213",
journal = "JACC: Heart Failure",
issn = "2213-1779",
publisher = "Elsevier BV",
number = "3",

}

RIS

TY - JOUR

T1 - Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe

T2 - Results From the BiomarCaRE Consortium

AU - Magnussen, Christina

AU - Niiranen, Teemu J

AU - Ojeda, Francisco M

AU - Gianfagna, Francesco

AU - Blankenberg, Stefan

AU - Vartiainen, Erkki

AU - Sans, Susana

AU - Pasterkamp, Gerard

AU - Hughes, Maria

AU - Costanzo, Simona

AU - Donati, Maria Benedetta

AU - Jousilahti, Pekka

AU - Linneberg, Allan

AU - Palosaari, Tarja

AU - de Gaetano, Giovanni

AU - Bobak, Martin

AU - den Ruijter, Hester M

AU - Jørgensen, Torben

AU - Söderberg, Stefan

AU - Kuulasmaa, Kari

AU - Zeller, Tanja

AU - Iacoviello, Licia

AU - Salomaa, Veikko

AU - Schnabel, Renate B

AU - BiomarCaRE Consortium

N1 - Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

PY - 2019/3

Y1 - 2019/3

N2 - OBJECTIVES: This study investigates differences between women and men in heart failure (HF) risk and mortality.BACKGROUND: Sex differences in HF epidemiology are insufficiently understood.METHODS: In 78,657 individuals (median 49.5 years of age; age range 24.1 to 98.7 years; 51.7% women) from community-based European studies (FINRISK, DanMONICA, Moli-sani, Northern Sweden) of the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium, the association between incident HF and mortality, the relationship of cardiovascular risk factors, prevalent cardiovascular diseases, biomarkers (C-reactive protein [CRP]; N-terminal pro-B-type natriuretic peptide [NT-proBNP]) with incident HF, and their attributable risks were tested in women vs. men.RESULTS: Over a median follow-up of 12.7 years, fewer HF cases were observed in women (n = 2,399 [5.9%]) than in men (n = 2,771 [7.3%]). HF incidence increased markedly after 60 years of age, initially with a more rapid increase in men, whereas incidence in women exceeded that of men after 85 years of age. HF onset substantially increased mortality risk in both sexes. Multivariable-adjusted Cox models showed the following sex differences for the association with incident HF: systolic blood pressure hazard ratio (HR) according to SD in women of 1.09 (95% confidence interval [CI]: 1.05 to 1.14) versus HR of 1.19 (95% CI: 1.14 to 1.24) in men; heart rate HR of 0.98 (95% CI: 0.93 to 1.03) in women versus HR of 1.09 (95% CI: 1.04 to 1.13) in men; CRP HR of 1.10 (95% CI: 1.00 to 1.20) in women versus HR of 1.32 (95% CI: 1.24 to 1.41) in men; and NT-proBNP HR of 1.54 (95% CI: 1.37 to 1.74) in women versus HR of 1.89 (95% CI: 1.75 to 2.05) in men. Population-attributable risk of all risk factors combined was 59.0% in women and 62.9% in men.CONCLUSIONS: Women had a lower risk for HF than men. Sex differences were seen for systolic blood pressure, heart rate, CRP, and NT-proBNP, with a lower HF risk in women.

AB - OBJECTIVES: This study investigates differences between women and men in heart failure (HF) risk and mortality.BACKGROUND: Sex differences in HF epidemiology are insufficiently understood.METHODS: In 78,657 individuals (median 49.5 years of age; age range 24.1 to 98.7 years; 51.7% women) from community-based European studies (FINRISK, DanMONICA, Moli-sani, Northern Sweden) of the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium, the association between incident HF and mortality, the relationship of cardiovascular risk factors, prevalent cardiovascular diseases, biomarkers (C-reactive protein [CRP]; N-terminal pro-B-type natriuretic peptide [NT-proBNP]) with incident HF, and their attributable risks were tested in women vs. men.RESULTS: Over a median follow-up of 12.7 years, fewer HF cases were observed in women (n = 2,399 [5.9%]) than in men (n = 2,771 [7.3%]). HF incidence increased markedly after 60 years of age, initially with a more rapid increase in men, whereas incidence in women exceeded that of men after 85 years of age. HF onset substantially increased mortality risk in both sexes. Multivariable-adjusted Cox models showed the following sex differences for the association with incident HF: systolic blood pressure hazard ratio (HR) according to SD in women of 1.09 (95% confidence interval [CI]: 1.05 to 1.14) versus HR of 1.19 (95% CI: 1.14 to 1.24) in men; heart rate HR of 0.98 (95% CI: 0.93 to 1.03) in women versus HR of 1.09 (95% CI: 1.04 to 1.13) in men; CRP HR of 1.10 (95% CI: 1.00 to 1.20) in women versus HR of 1.32 (95% CI: 1.24 to 1.41) in men; and NT-proBNP HR of 1.54 (95% CI: 1.37 to 1.74) in women versus HR of 1.89 (95% CI: 1.75 to 2.05) in men. Population-attributable risk of all risk factors combined was 59.0% in women and 62.9% in men.CONCLUSIONS: Women had a lower risk for HF than men. Sex differences were seen for systolic blood pressure, heart rate, CRP, and NT-proBNP, with a lower HF risk in women.

U2 - 10.1016/j.jchf.2018.08.008

DO - 10.1016/j.jchf.2018.08.008

M3 - Journal article

VL - 7

SP - 204

EP - 213

JO - JACC: Heart Failure

JF - JACC: Heart Failure

SN - 2213-1779

IS - 3

ER -

ID: 56741035