TY - JOUR
T1 - Sex-Specific Associations Between Thyrotropin and Serum Lipid Profiles
AU - Meisinger, Christa
AU - Ittermann, Till
AU - Tiller, Daniel
AU - Agger, Carsten
AU - Nauck, Matthias
AU - Schipf, Sabine
AU - Wallaschofski, Henri
AU - Jørgensen, Torben
AU - Linneberg, Allan
AU - Thiery, Joachim
AU - Kluttig, Alexander
AU - Greiser, Karin H
AU - Werdan, Karl
AU - Burkhardt, Katrin
AU - Völzke, Henry
PY - 2014/3
Y1 - 2014/3
N2 - Background: Population-based studies investigating the sex-specific association between thyrotropin (TSH) levels and serum lipid concentrations are scarce. We examined the association between TSH and total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and triglycerides in men and women from the general population. Furthermore, the association with TSH outside and within the reference range and lipid levels was studied. Methods: Individual data of 13,571 men and women without lipid medication of four population-based studies conducted in Western European adults were pooled for cross-sectional analyses. The association between TSH levels and lipid concentrations were analyzed by calculating sex-specific multivariable median regression models. Results: In the pooled population, serum TSH levels were significantly positively associated with triglyceride values in men and with total cholesterol, LDL cholesterol, and triglyceride values in women. In the pooled male population, low serum TSH levels (
AB - Background: Population-based studies investigating the sex-specific association between thyrotropin (TSH) levels and serum lipid concentrations are scarce. We examined the association between TSH and total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and triglycerides in men and women from the general population. Furthermore, the association with TSH outside and within the reference range and lipid levels was studied. Methods: Individual data of 13,571 men and women without lipid medication of four population-based studies conducted in Western European adults were pooled for cross-sectional analyses. The association between TSH levels and lipid concentrations were analyzed by calculating sex-specific multivariable median regression models. Results: In the pooled population, serum TSH levels were significantly positively associated with triglyceride values in men and with total cholesterol, LDL cholesterol, and triglyceride values in women. In the pooled male population, low serum TSH levels (
U2 - 10.1089/thy.2013.0259
DO - 10.1089/thy.2013.0259
M3 - Journal article
C2 - 24102572
SN - 1050-7256
VL - 24
SP - 424
EP - 432
JO - Thyroid : official journal of the American Thyroid Association
JF - Thyroid : official journal of the American Thyroid Association
IS - 3
ER -