Severity of COVID19 infection among patients with multiple sclerosis treated with interferon-β

Steve Simpson-Yap; Ashkan Pirmani; Edward De Brouwer; Liesbet M Peeters; Lotte Geys; Tina Parciak; Anne Helme; Jan Hillert; Yves Moreau; Gilles Edan; Tim Spelman; Sifat Sharmin; Robert McBurney; Hollie Schmidt; Arnfin Bergmann; Stefan Braune; Alexander Stahmann; Rodden Middleton; Amber Salter; Bruce Bebo; Anneke van der Walt; Helmut Butzkueven; Serkan Ozakbas; Rana Karabudak; Cavit Boz; Raed Alroughani; Juan I Rojas; Ingrid van der Mei; Guilherme Sciascia do Olival; Melinda Magyari; Ricardo Alonso; Richard Nicholas; Anibal Chertcoff; Ana Zabalza; Georgina Arrambide; Nupur Nag; Annabel Descamps; Lars Costers; Ruth Dobson; Aleisha Miller; Paulo Rodrigues; Vesna Prčkovska; Giancarlo Comi; Tomas Kalincik

doi:10.1016/j.msard.2022.104072

Severity of COVID19 infection among patients with multiple sclerosis treated with interferon-β

Steve Simpson-Yap, Ashkan Pirmani, Edward De Brouwer, Liesbet M Peeters, Lotte Geys, Tina Parciak, Anne Helme, Jan Hillert, Yves Moreau, Gilles Edan, Tim Spelman, Sifat Sharmin, Robert McBurney, Hollie Schmidt, Arnfin Bergmann, Stefan Braune, Alexander Stahmann, Rodden Middleton, Amber Salter, Bruce BeboAnneke van der Walt, Helmut Butzkueven, Serkan Ozakbas, Rana Karabudak, Cavit Boz, Raed Alroughani, Juan I Rojas, Ingrid van der Mei, Guilherme Sciascia do Olival, Melinda Magyari, Ricardo Alonso, Richard Nicholas, Anibal Chertcoff, Ana Zabalza, Georgina Arrambide, Nupur Nag, Annabel Descamps, Lars Costers, Ruth Dobson, Aleisha Miller, Paulo Rodrigues, Vesna Prčkovska, Giancarlo Comi, Tomas Kalincik

Afdeling for Hjerne- og Nervesygdomme

Abstract

BACKGROUND: Interferon-β, a disease-modifying therapy (DMT) for MS, may be associated with less severe COVID-19 in people with MS.

RESULTS: Among 5,568 patients (83.4% confirmed COVID-19), interferon-treated patients had lower risk of severe COVID-19 compared to untreated, but not to glatiramer-acetate, dimethyl-fumarate, or pooled other DMTs.

CONCLUSIONS: In comparison to other DMTs, we did not find evidence of protective effects of interferon-β on the severity of COVID-19, though compared to the untreated, the course of COVID19 was milder among those on interferon-β. This study does not support the use of interferon-β as a treatment to reduce COVID-19 severity in MS.

Originalsprog	Engelsk
Artikelnummer	104072
Tidsskrift	Multiple Sclerosis and Related Disorders
Vol/bind	66
Sider (fra-til)	1-5
Antal sider	5
ISSN	2211-0348
DOI	https://doi.org/10.1016/j.msard.2022.104072
Status	Udgivet - 2022

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10.1016/j.msard.2022.104072

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Simpson-Yap, S., Pirmani, A., De Brouwer, E., Peeters, L. M., Geys, L., Parciak, T., Helme, A., Hillert, J., Moreau, Y., Edan, G., Spelman, T., Sharmin, S., McBurney, R., Schmidt, H., Bergmann, A., Braune, S., Stahmann, A., Middleton, R., Salter, A., ... Kalincik, T. (2022). Severity of COVID19 infection among patients with multiple sclerosis treated with interferon-β. Multiple Sclerosis and Related Disorders, 66, 1-5. Artikel 104072. https://doi.org/10.1016/j.msard.2022.104072

Simpson-Yap, S, Pirmani, A, De Brouwer, E, Peeters, LM, Geys, L, Parciak, T, Helme, A, Hillert, J, Moreau, Y, Edan, G, Spelman, T, Sharmin, S, McBurney, R, Schmidt, H, Bergmann, A, Braune, S, Stahmann, A, Middleton, R, Salter, A, Bebo, B, van der Walt, A, Butzkueven, H, Ozakbas, S, Karabudak, R, Boz, C, Alroughani, R, Rojas, JI, van der Mei, I, Sciascia do Olival, G, Magyari, M, Alonso, R, Nicholas, R, Chertcoff, A, Zabalza, A, Arrambide, G, Nag, N, Descamps, A, Costers, L, Dobson, R, Miller, A, Rodrigues, P, Prčkovska, V, Comi, G & Kalincik, T 2022, 'Severity of COVID19 infection among patients with multiple sclerosis treated with interferon-β', Multiple Sclerosis and Related Disorders, bind 66, 104072, s. 1-5. https://doi.org/10.1016/j.msard.2022.104072

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title = "Severity of COVID19 infection among patients with multiple sclerosis treated with interferon-β",

abstract = "BACKGROUND: Interferon-β, a disease-modifying therapy (DMT) for MS, may be associated with less severe COVID-19 in people with MS.RESULTS: Among 5,568 patients (83.4% confirmed COVID-19), interferon-treated patients had lower risk of severe COVID-19 compared to untreated, but not to glatiramer-acetate, dimethyl-fumarate, or pooled other DMTs.CONCLUSIONS: In comparison to other DMTs, we did not find evidence of protective effects of interferon-β on the severity of COVID-19, though compared to the untreated, the course of COVID19 was milder among those on interferon-β. This study does not support the use of interferon-β as a treatment to reduce COVID-19 severity in MS.",

author = "Steve Simpson-Yap and Ashkan Pirmani and {De Brouwer}, Edward and Peeters, {Liesbet M} and Lotte Geys and Tina Parciak and Anne Helme and Jan Hillert and Yves Moreau and Gilles Edan and Tim Spelman and Sifat Sharmin and Robert McBurney and Hollie Schmidt and Arnfin Bergmann and Stefan Braune and Alexander Stahmann and Rodden Middleton and Amber Salter and Bruce Bebo and {van der Walt}, Anneke and Helmut Butzkueven and Serkan Ozakbas and Rana Karabudak and Cavit Boz and Raed Alroughani and Rojas, {Juan I} and {van der Mei}, Ingrid and {Sciascia do Olival}, Guilherme and Melinda Magyari and Ricardo Alonso and Richard Nicholas and Anibal Chertcoff and Ana Zabalza and Georgina Arrambide and Nupur Nag and Annabel Descamps and Lars Costers and Ruth Dobson and Aleisha Miller and Paulo Rodrigues and Vesna Pr{\v c}kovska and Giancarlo Comi and Tomas Kalincik",

year = "2022",

doi = "10.1016/j.msard.2022.104072",

language = "English",

volume = "66",

pages = "1--5",

journal = "Multiple Sclerosis and Related Disorders",

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T1 - Severity of COVID19 infection among patients with multiple sclerosis treated with interferon-β

AU - Simpson-Yap, Steve

AU - Pirmani, Ashkan

AU - De Brouwer, Edward

AU - Peeters, Liesbet M

AU - Geys, Lotte

AU - Parciak, Tina

AU - Helme, Anne

AU - Hillert, Jan

AU - Moreau, Yves

AU - Edan, Gilles

AU - Spelman, Tim

AU - Sharmin, Sifat

AU - McBurney, Robert

AU - Schmidt, Hollie

AU - Bergmann, Arnfin

AU - Braune, Stefan

AU - Stahmann, Alexander

AU - Middleton, Rodden

AU - Salter, Amber

AU - Bebo, Bruce

AU - van der Walt, Anneke

AU - Butzkueven, Helmut

AU - Ozakbas, Serkan

AU - Karabudak, Rana

AU - Boz, Cavit

AU - Alroughani, Raed

AU - Rojas, Juan I

AU - van der Mei, Ingrid

AU - Sciascia do Olival, Guilherme

AU - Magyari, Melinda

AU - Alonso, Ricardo

AU - Nicholas, Richard

AU - Chertcoff, Anibal

AU - Zabalza, Ana

AU - Arrambide, Georgina

AU - Nag, Nupur

AU - Descamps, Annabel

AU - Costers, Lars

AU - Dobson, Ruth

AU - Miller, Aleisha

AU - Rodrigues, Paulo

AU - Prčkovska, Vesna

AU - Comi, Giancarlo

AU - Kalincik, Tomas

PY - 2022

Y1 - 2022

N2 - BACKGROUND: Interferon-β, a disease-modifying therapy (DMT) for MS, may be associated with less severe COVID-19 in people with MS.RESULTS: Among 5,568 patients (83.4% confirmed COVID-19), interferon-treated patients had lower risk of severe COVID-19 compared to untreated, but not to glatiramer-acetate, dimethyl-fumarate, or pooled other DMTs.CONCLUSIONS: In comparison to other DMTs, we did not find evidence of protective effects of interferon-β on the severity of COVID-19, though compared to the untreated, the course of COVID19 was milder among those on interferon-β. This study does not support the use of interferon-β as a treatment to reduce COVID-19 severity in MS.

AB - BACKGROUND: Interferon-β, a disease-modifying therapy (DMT) for MS, may be associated with less severe COVID-19 in people with MS.RESULTS: Among 5,568 patients (83.4% confirmed COVID-19), interferon-treated patients had lower risk of severe COVID-19 compared to untreated, but not to glatiramer-acetate, dimethyl-fumarate, or pooled other DMTs.CONCLUSIONS: In comparison to other DMTs, we did not find evidence of protective effects of interferon-β on the severity of COVID-19, though compared to the untreated, the course of COVID19 was milder among those on interferon-β. This study does not support the use of interferon-β as a treatment to reduce COVID-19 severity in MS.

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U2 - 10.1016/j.msard.2022.104072

DO - 10.1016/j.msard.2022.104072

M3 - Letter

C2 - 35917745

SN - 2211-0348

VL - 66

SP - 1

EP - 5

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

M1 - 104072

ER -

Severity of COVID19 infection among patients with multiple sclerosis treated with interferon-β

Abstract

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