Serum YKL-40: a new independent prognostic marker for skeletal complications in patients with multiple myeloma

Anne K Mylin, Niels Abildgaard, Julia S Johansen, Lene Heickendorff, Svend Kreiner, Anders Waage, Ingemar Turesson, Peter Gimsing, for the Nordic Myeloma Study Group

19 Citationer (Scopus)

Abstract

In a time of increasing treatment options for multiple myeloma bone disease, risk factors predicting progression need to be elucidated. This study investigated the value of serum YKL-40, previously shown to be associated with radiographic progression of bone destruction, as a predictor for time to clinical progression, i.e. skeletal-related events (SREs), in 230 newly diagnosed patients with multiple myeloma receiving intravenous bisphosphonates. Serum concentrations of YKL-40 and biochemical bone markers (CTX-MMP, CTX-I, PINP) were measured at diagnosis. Patients were evaluated every third month for SRE and at 9 and 24 months for radiographic progression. Elevated serum YKL-40 was seen in 47% of patients and associated with high-risk disease (International Staging System stage III; p < 0.001), increased bone resorption (serum CTX/MMP; p < 0.001) and early radiographic progression at 9 months (p = 0.01). Serum YKL-40 together with serum CTX-MMP/PINP ratio and World Health Organization status were independent predictors of time to first SRE.

OriginalsprogEngelsk
TidsskriftLeukemia and Lymphoma
Vol/bind56
Udgave nummer9
Sider (fra-til)2650-59
Antal sider1
ISSN1042-8194
DOI
StatusUdgivet - 11 feb. 2015

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