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Serum urate as a proposed surrogate outcome measure in gout trials: From the OMERACT working group

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  • Melanie Birger Morillon
  • Robin Christensen
  • Jasvinder A Singh
  • Nicola Dalbeth
  • Kenneth Saag
  • William J Taylor
  • Tuhina Neogi
  • Martin A Kennedy
  • Birthe M Pedersen
  • Geraldine M McCarthy
  • Beverley Shea
  • Cesar Diaz-Torne
  • Sara K Tedeschi
  • Rebecca Grainger
  • Abhishek Abhishek
  • Angelo Gaffo
  • Sabrina Mai Nielsen
  • Alexander Noerup
  • Lee S Simon
  • Marissa Lassere
  • Peter Tugwell
  • Lisa K Stamp
  • For The Omeract Gout Working Group
Vis graf over relationer

Serum urate (SU) is the most common primary efficacy outcome in trials of urate-lowering therapies for gout. Despite this, it is not formally considered a validated surrogate outcome. In this paper we will outline the definitions of biomarkers and surrogate outcome measures, respectively as well as the available frameworks and challenges in the assessment of the validity of serum urate as a surrogate in gout (i.e. a reasonable replacement for gout symptoms).

OriginalsprogEngelsk
TidsskriftSeminars in Arthritis and Rheumatism
Vol/bind51
Udgave nummer6
Sider (fra-til)1378-1385
Antal sider8
ISSN0049-0172
DOI
StatusUdgivet - dec. 2021

Bibliografisk note

Copyright © 2021 Elsevier Inc. All rights reserved.

ID: 70330157