Serum testosterone as a prognostic factor in patients with advanced prostatic carcinoma

P Iversen, F Rasmussen, I J Christensen

    45 Citationer (Scopus)

    Abstract

    In 245 patients with previously untreated advanced carcinoma of the prostate, serum concentrations of testosterone have been measured before androgen deprivation therapy, and patients were divided in quartiles according to their serum concentration. Pretreatment level of serum testosterone was confirmed as having significant prognostic value on progression-free, overall, and cancer-specific survival, and the hazard ratios of lower quartiles compared to the upper quartile for these endpoints were 2.3, 2.1, and 2.0, respectively. However, correlations with symptomatology and other pretreatment parameters suggest that low serum testosterone merely is a consequence of the advanced malignancy rather than a causative factor in the pathogenesis of prostatic cancer.
    OriginalsprogEngelsk
    BogserieScandinavian Journal of Urology and Nephrology. Supplement
    Vol/bind157
    Sider (fra-til)41-7
    Antal sider7
    ISSN0300-8886
    StatusUdgivet - 1994

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