Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Serum selenium level and risk of lung cancer mortality

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Prognostic significance of chronic respiratory symptoms in individuals with normal spirometry

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  2. Budesonide/formoterol maintenance and reliever therapy in adolescent patients with asthma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α1-antitrypsin deficiency

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Inducible laryngeal obstruction: an official joint European Respiratory Society and European Laryngological Society statement

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Perceived stress and dementia: Results from the Copenhagen city heart study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Midlife cardiorespiratory fitness and the long-term risk of chronic obstructive pulmonary disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Serum selenium has been implicated as a risk factor for lung cancer, but the issue remains unsettled. We tested in a cohort of 3,333 males aged 53 to 74 years the hypothesis that a low serum selenium would be associated with an increased risk of lung cancer mortality.During 16 years, 167 subjects(5.1%) died from lung cancer; 48 males (5.0%) among males with low serum selenium, 0.4-1.0 μmol·l(-1), n=965, 57 males (5.1%) among males with medium serum selenium, 1.1-1.2 μmol·l(-1), n=1,141, and 62 males (5.1%) among males with high serum selenium, 1.3-3.0 μmol·l(-1), n=1,227. After adjustment for age, referencing the lowest level of serum selenium hazard ratios with 95% CI (HR) for medium and high levels of serum selenium were 0.97(0.66-1.43), and 0.99(0.68-1.45), respectively. Taking into account pack years of smoking, spirits intake, dietary markers (salt and fat preferences), and health measures (chronic bronchitis and peak flow), referencing the lowest level of serum selenium HRs were 1.17(0.79-1.75), and 1.43(0.96-2.14), respectively. Among heavy smokers a high serum selenium was associated with a significantly increased risk of lung cancer mortality after taking into account all potential confounders. The hypothesis that low serum selenium is an independent risk factor for lung cancer was not supported.
OriginalsprogEngelsk
TidsskriftEuropean Respiratory Journal
ISSN0903-1936
DOI
StatusUdgivet - 2011

ID: 34793043