Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland

Linus Kvist, Yvonne Lundberg Giwercman, Bo A G Jönsson, Christian H Lindh, Gunnar Toft, Pawel Strucinski, Henning S Pedersen, Valentyna Zvyezday, Aleksander Giwercman, Jens Peter Ellekilde Bonde

19 Citationer (Scopus)

Abstract

This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass spectrometry. Data was analyzed by linear and nonlinear regression. We observed no associations between PFOA and Y:X ratio (p=0.845 in a linear model, p=0.296 in a nonlinear model). A positive nonlinear association between PFOS and Y:X ratio was observed (p=0.016), with no association in a linear model (p=0.118). Analyzing the populations separately, a negative trend between categorized PFOS exposure and Y:X ratio was observed for the Inuit (B=-0.002, p=0.044). In conclusion, there was a negative trend between Y:X ratio and PFOS in the Inuit, while there was no association between PFOA and the Y:X ratio in adult men.
OriginalsprogEngelsk
TidsskriftReproductive Toxicology
Vol/bind34
Udgave nummer4
Sider (fra-til)644-50
Antal sider7
ISSN0890-6238
DOI
StatusUdgivet - 2012

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