Serum inhibin A and inhibin B in central precocious puberty before and during treatment with GnRH agonists

A Sehested; A M Andersson; J Müller; N E Skakkebaek

doi:53237

Serum inhibin A and inhibin B in central precocious puberty before and during treatment with GnRH agonists

A Sehested, A M Andersson, J Müller, N E Skakkebaek

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Abstract

Serum levels of the gonadal hormones inhibin A and inhibin B are undetectable or low in prepubertal girls, and rise during puberty. In girls with central precocious puberty (CPP) the hypothalamic-pituitary-gonadal axis is prematurely activated, if the girl is thereafter treated with GnRH agonists both gonadotropins and estradiol levels become suppressed. We therefore investigated serum levels of inhibin A and inhibin B in girls with CPP at diagnosis and during treatment in order to test the hypothesis that inhibin secretion would increase and decrease in parallel with the activation and suppression of the hypothalamic-pituitary-gonadal axis. Serum levels of inhibin A and inhibin B were significantly (p <0.0005) elevated in 42 girls at diagnosis of CPP (inhibin A: 7 pg/ml (

Originalsprog	Engelsk
Tidsskrift	Hormone Research
Vol/bind	54
Udgave nummer	2
Sider (fra-til)	84-91
Antal sider	8
ISSN	0301-0163
DOI	https://doi.org/53237
Status	Udgivet - 2000

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53237

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@article{67a28e6403154c5fa957969d4b1de6b2,

title = "Serum inhibin A and inhibin B in central precocious puberty before and during treatment with GnRH agonists",

abstract = "Serum levels of the gonadal hormones inhibin A and inhibin B are undetectable or low in prepubertal girls, and rise during puberty. In girls with central precocious puberty (CPP) the hypothalamic-pituitary-gonadal axis is prematurely activated, if the girl is thereafter treated with GnRH agonists both gonadotropins and estradiol levels become suppressed. We therefore investigated serum levels of inhibin A and inhibin B in girls with CPP at diagnosis and during treatment in order to test the hypothesis that inhibin secretion would increase and decrease in parallel with the activation and suppression of the hypothalamic-pituitary-gonadal axis. Serum levels of inhibin A and inhibin B were significantly (p <0.0005) elevated in 42 girls at diagnosis of CPP (inhibin A: 7 pg/ml (",

keywords = "Buserelin, Child, Child, Preschool, Cyproterone Acetate, Female, Fertility, Follow-Up Studies, Gonadotropin-Releasing Hormone, Humans, Inhibins, Prostatic Secretory Proteins, Puberty, Precocious, Triptorelin Pamoate",

author = "A Sehested and Andersson, {A M} and J M{\"u}ller and Skakkebaek, {N E}",

year = "2000",

doi = "53237",

language = "English",

volume = "54",

pages = "84--91",

journal = "Hormone Research",

issn = "0301-0163",

publisher = "S./Karger AG",

number = "2",

}

TY - JOUR

T1 - Serum inhibin A and inhibin B in central precocious puberty before and during treatment with GnRH agonists

AU - Sehested, A

AU - Andersson, A M

AU - Müller, J

AU - Skakkebaek, N E

PY - 2000

Y1 - 2000

N2 - Serum levels of the gonadal hormones inhibin A and inhibin B are undetectable or low in prepubertal girls, and rise during puberty. In girls with central precocious puberty (CPP) the hypothalamic-pituitary-gonadal axis is prematurely activated, if the girl is thereafter treated with GnRH agonists both gonadotropins and estradiol levels become suppressed. We therefore investigated serum levels of inhibin A and inhibin B in girls with CPP at diagnosis and during treatment in order to test the hypothesis that inhibin secretion would increase and decrease in parallel with the activation and suppression of the hypothalamic-pituitary-gonadal axis. Serum levels of inhibin A and inhibin B were significantly (p <0.0005) elevated in 42 girls at diagnosis of CPP (inhibin A: 7 pg/ml (

AB - Serum levels of the gonadal hormones inhibin A and inhibin B are undetectable or low in prepubertal girls, and rise during puberty. In girls with central precocious puberty (CPP) the hypothalamic-pituitary-gonadal axis is prematurely activated, if the girl is thereafter treated with GnRH agonists both gonadotropins and estradiol levels become suppressed. We therefore investigated serum levels of inhibin A and inhibin B in girls with CPP at diagnosis and during treatment in order to test the hypothesis that inhibin secretion would increase and decrease in parallel with the activation and suppression of the hypothalamic-pituitary-gonadal axis. Serum levels of inhibin A and inhibin B were significantly (p <0.0005) elevated in 42 girls at diagnosis of CPP (inhibin A: 7 pg/ml (

KW - Buserelin

KW - Child

KW - Child, Preschool

KW - Cyproterone Acetate

KW - Female

KW - Fertility

KW - Follow-Up Studies

KW - Gonadotropin-Releasing Hormone

KW - Humans

KW - Inhibins

KW - Prostatic Secretory Proteins

KW - Puberty, Precocious

KW - Triptorelin Pamoate

U2 - 53237

DO - 53237

M3 - Journal article

C2 - 11251372

SN - 0301-0163

VL - 54

SP - 84

EP - 91

JO - Hormone Research

JF - Hormone Research

IS - 2

ER -

Serum inhibin A and inhibin B in central precocious puberty before and during treatment with GnRH agonists

Abstract

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