Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Serum chemerin levels are inversely associated with renal function in a general population

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Sex differences in acromegaly at diagnosis: A nationwide cohort study and meta-analysis of the literature

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Increased levels of inflammatory factors are associated with severity of polyneuropathy in type 1 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Reproductive Hormones During Pubertal Transition in Girls with Transient Thelarche

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Phenotypic and genotypic features of a large kindred with a germline AIP variant

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Changes in subtypes of overt thyrotoxicosis and hypothyroidism following iodine fortification

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Estimating the causal effect of body mass index on hay fever, asthma and lung function using Mendelian randomization

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Stephanie Zylla
  • Rainer Rettig
  • Henry Völzke
  • Karlhans Endlich
  • Matthias Nauck
  • Nele Friedrich
Vis graf over relationer

OBJECTIVE: Chemerin has been found to be highly expressed in the kidneys of rodents and has been suggested to affect metabolic syndrome (MetS)-related phenotypes which are in turn related to kidney damage. Only few clinical studies have addressed the relation between circulating chemerin and renal function in humans, and no population-based analyses have yet been performed. The potential influence of MetS-related phenotypes on the assumed association has been largely neglected. We aimed to investigate the association of serum chemerin with renal function in a general population with special regard to possible interactions between chemerin and metabolic phenotypes.

DESIGN, PATIENTS AND MEASUREMENTS: Linear and logistic regression models were applied to analyse data from 4082 subjects of the German Study of Health in Pomerania. Main outcomes included estimated glomerular filtration rate (eGFR), serum creatinine and cystatin C and chronic kidney disease.

RESULTS: Inverse associations of chemerin with eGFR were observed. The components of the MetS emerged as modulating factors in this relation and enhanced the association. Logistic regression models confirmed the relation between chemerin and eGFR and revealed that each increase in chemerin per 25 ng/mL was associated with an about threefold higher odds of chronic kidney disease [odds ratio 2.72 (95% confidence interval 2.26-3.29)].

CONCLUSIONS: Our results demonstrate a strong inverse association between serum chemerin levels and renal function. This association might be explained by MetS-related phenotypes, which lead to renal damage and are associated with increased chemerin levels and/or an impaired renal elimination of chemerin by diseased kidneys.

OriginalsprogEngelsk
TidsskriftClinical Endocrinology
Vol/bind88
Udgave nummer1
Sider (fra-til)146-153
Antal sider8
ISSN0300-0664
DOI
StatusUdgivet - 2018

ID: 52617671