Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Sertoli Cell Number Correlates with Serum Inhibin B in Infant Cryptorchid Boys

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Surgical Management of Undescended Testis - Timetable and Outcome: A Debate

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Building the mammalian testis: origins, differentiation, and assembly of the component cell populations

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Gonocyte transformation in congenital undescended testes: what is the role of inhibin-B in cell death?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Xeno-Free Propagation of Spermatogonial Stem Cells from Infant Boys

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Propagation of Spermatogonial Stem Cell-Like Cells From Infant Boys

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Associations of different molecular forms of antimüllerian hormone and biomarkers of polycystic ovary syndrome and normal women

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Postnatal maturation of Sertoli cells is crucial for male fertility. The aim of this study was to assess the association between the Sertoli cell number per tubule cross-section (SC/T), the serum level of the Sertoli cell-produced inhibin B, and the A-dark spermatogonia number per tubule (Ad/T) in cryptorchid boys. Forty infant cryptorchid boys aged 4-35 months (median: 13 months) were included in the study. During orchiopexy, blood samples for serum inhibin B, luteinizing hormone (LH), and follicle stimulating hormone (FSH) and testicular biopsies were obtained. Histological sections were evaluated by quantitative immunohistochemical and immunofluorescence analysis including VASA and SOX9 (Sertoli cell marker) in order to measure the tubular germ cell number (G/T), Ad/T, and SC/T. The SC/T correlated negatively with age (p < 0.0002) and positively with G/T, Ad/T, inhibin B, FSH, and LH (all p < 0.01). Inhibin B correlated with LH (p < 0.0001), but not with FSH (p = 0.2077). The SC/T:G/T ratio positively correlated with age (p < 0.0001). Boys with Ad spermatogonia at surgery had a higher number of Sertoli cells compared to boys without Ad spermatogonia. In conclusion, a correlation between Sertoli cell number and inhibin B was proven, indicating that inhibin B possibly reflects the function of Sertoli cells in infant cryptorchid boys.

OriginalsprogEngelsk
TidsskriftGenes and Development
Vol/bind13
Udgave nummer2
Sider (fra-til)74-82
Antal sider9
ISSN0890-9369
DOI
StatusUdgivet - 1 jun. 2019

Bibliografisk note

© 2019 S. Karger AG, Basel.

ID: 56874069