Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites

Philip Bejon, Louise Turner, Thomas Lavstsen, Gerald Kennedy Cham Kpu, Ally Olotu, Chris J Drakeley, Marc Lievens, Johan Vekemans, Barbara Savarese, John Lusingu, Lorenz von Seidlein, Peter H. Bull, Kevin Marsh, Thor G Theander

    32 Citationer (Scopus)


    Malaria transmission may be considered to be homogenous with well-mixed parasite populations (as in the classic Ross/Macdonald models). Marked fine-scale heterogeneity of transmission has been observed in the field (i.e., over a few kilometres), but there are relatively few data on the degree of mixing. Since the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) is highly polymorphic, the host's serological responses may be used to infer exposure to parasite sub-populations.
    TidsskriftP L o S One
    Udgave nummer6
    Sider (fra-til)e21711
    StatusUdgivet - 1 jan. 2011


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