Sequential combination of glucocorticosteroids and alfa interferon versus alfa interferon alone for HBeAg-positive chronic hepatitis B

M T Mellerup; K Krogsgaard; P Mathurin; C Gluud; T Poynard

doi:10.1002/14651858.CD000345.pub2

Sequential combination of glucocorticosteroids and alfa interferon versus alfa interferon alone for HBeAg-positive chronic hepatitis B

M T Mellerup
, K Krogsgaard
, P Mathurin
, C Gluud
, T Poynard

Copenhagen Trial Unit Rigshospitalet

14 Citationer (Scopus)

Abstract

Chronic hepatitis B has serious effects on morbidity and mortality. Alfa interferon has been shown to increase the rates of HBeAg-clearance as well as seroconversion to anti-HBe, but response rates are unsatisfactory. Glucocorticosteroid pretreatment may increase the response to alfa interferon.

Originalsprog	Engelsk
Tidsskrift	Cochrane Database of Systematic Reviews
Udgave nummer	3
Sider (fra-til)	CD000345
ISSN	1469-493X
DOI	https://doi.org/10.1002/14651858.CD000345.pub2
Status	Udgivet - 2005

Adgang til dokumentet

10.1002/14651858.CD000345.pub2

Citationsformater

@article{c8884954ced843f48f026d8e6788b30d,

title = "Sequential combination of glucocorticosteroids and alfa interferon versus alfa interferon alone for HBeAg-positive chronic hepatitis B",

abstract = "Chronic hepatitis B has serious effects on morbidity and mortality. Alfa interferon has been shown to increase the rates of HBeAg-clearance as well as seroconversion to anti-HBe, but response rates are unsatisfactory. Glucocorticosteroid pretreatment may increase the response to alfa interferon.",

keywords = "Antiviral Agents, Drug Therapy, Combination, Glucocorticoids, Hepatitis B Antibodies, Hepatitis B e Antigens, Hepatitis B, Chronic, Humans, Interferon-alpha, Randomized Controlled Trials as Topic",

author = "Mellerup, \{M T\} and K Krogsgaard and P Mathurin and C Gluud and T Poynard",

year = "2005",

doi = "10.1002/14651858.CD000345.pub2",

language = "English",

pages = "CD000345",

journal = "Cochrane Database of Systematic Reviews",

issn = "1469-493X",

publisher = "John Wiley and Sons Ltd",

number = "3",

}

TY - JOUR

T1 - Sequential combination of glucocorticosteroids and alfa interferon versus alfa interferon alone for HBeAg-positive chronic hepatitis B

AU - Mellerup, M T

AU - Krogsgaard, K

AU - Mathurin, P

AU - Gluud, C

AU - Poynard, T

PY - 2005

Y1 - 2005

N2 - Chronic hepatitis B has serious effects on morbidity and mortality. Alfa interferon has been shown to increase the rates of HBeAg-clearance as well as seroconversion to anti-HBe, but response rates are unsatisfactory. Glucocorticosteroid pretreatment may increase the response to alfa interferon.

AB - Chronic hepatitis B has serious effects on morbidity and mortality. Alfa interferon has been shown to increase the rates of HBeAg-clearance as well as seroconversion to anti-HBe, but response rates are unsatisfactory. Glucocorticosteroid pretreatment may increase the response to alfa interferon.

KW - Antiviral Agents

KW - Drug Therapy, Combination

KW - Glucocorticoids

KW - Hepatitis B Antibodies

KW - Hepatitis B e Antigens

KW - Hepatitis B, Chronic

KW - Humans

KW - Interferon-alpha

KW - Randomized Controlled Trials as Topic

U2 - 10.1002/14651858.CD000345.pub2

DO - 10.1002/14651858.CD000345.pub2

M3 - Journal article

C2 - 16034852

SN - 1469-493X

SP - CD000345

JO - Cochrane Database of Systematic Reviews

JF - Cochrane Database of Systematic Reviews

IS - 3

ER -

Sequential combination of glucocorticosteroids and alfa interferon versus alfa interferon alone for HBeAg-positive chronic hepatitis B

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater