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Udgivet

Separation of steroid isomers by ion mobility mass spectrometry

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  • Linda Ahonen
  • Maíra Fasciotti
  • Gustav Boije af Gennäs
  • Tapio Kotiaho
  • Romeu J. Daroda
  • Marcos Eberlin
  • Risto Kostiainen
Vis graf over relationer

Ion mobility mass spectrometry performed in a compact traveling wave cell (TWIM-MS) is shown to provide a reliable, fast and repeatable method to separate derivatized steroid isomers. Three steroid isomer pairs were analyzed in their native form and as their p-toluenesulfonyl isocyanate derivatives. The native steroids were separated from each other, but no separation could be attained for the isomers. The derivatized steroid isomers were, however, properly separated by TWIM-MS with peak-to-peak resolutions close to or as high as baseline resolution (Rp-p=0.77-1.08).

OriginalsprogEngelsk
TidsskriftJournal of Chromatography A
Vol/bind1310
Sider (fra-til)133-137
Antal sider5
ISSN0021-9673
DOI
StatusUdgivet - 4 okt. 2013
Eksternt udgivetJa

ID: 54965605