Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion

Søren Jensen, Allan Randrup Thomsen

Abstract

Our knowledge regarding the contribution of the innate immune system in recognizing and subsequently initiating a host response to an invasion of RNA virus has been rapidly growing over the last decade. Descriptions of the receptors involved and the molecular mechanisms they employ to sense viral pathogen-associated molecular patterns have emerged in great detail. This review presents an overview of our current knowledge regarding the receptors used to detect RNA virus invasion, the molecular structures these receptors sense, and the involved downstream signaling pathways.

OriginalsprogEngelsk
TidsskriftJournal of Virology
Vol/bind86
Udgave nummer6
Sider (fra-til)2900-10
Antal sider11
ISSN0022-538X
DOI
StatusUdgivet - mar. 2012
Udgivet eksterntJa

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