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Sensation, mechanoreceptor, and nerve fiber function after nerve regeneration

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Krarup, Christian ; Rosén, Birgitta ; Boeckstyns, Michel ; Ibsen Sørensen, Allan ; Lundborg, Göran ; Moldovan, Mihai ; Archibald, Simon J. / Sensation, mechanoreceptor, and nerve fiber function after nerve regeneration. I: Annals of Neurology. 2017 ; Bind 82, Nr. 6. s. 940-950.

Bibtex

@article{532972b5677a4a7da346cf6483b26710,
title = "Sensation, mechanoreceptor, and nerve fiber function after nerve regeneration",
abstract = "OBJECTIVE: Sensation is essential for recovery after peripheral nerve injury. However, the relationship between sensory modalities and function of regenerated fibers is uncertain. We have investigated the relationships between touch threshold, tactile gnosis, and mechanoreceptor and sensory fiber function after nerve regeneration.METHODS: Twenty-one median or ulnar nerve lesions were repaired by a collagen nerve conduit or direct suture. Quantitative sensory hand function and sensory conduction studies by near-nerve technique, including tactile stimulation of mechanoreceptors, were followed for 2 years, and results were compared to noninjured hands.RESULTS: At both repair methods, touch thresholds at the finger tips recovered to 81 ± 3% and tactile gnosis only to 20 ± 4% (p < 0.001) of control. The sensory nerve action potentials (SNAPs) remained dispersed and areas recovered to 23 ± 2% and the amplitudes only to 7 ± 1% (P < 0.001). The areas of SNAPs after tactile stimulation recovered to 61 ± 11% and remained slowed. Touch sensation correlated with SNAP areas (p < 0.005) and was negatively related to the prolongation of tactile latencies (p < 0.01); tactile gnosis was not related to electrophysiological parameters.INTERPRETATION: The recovered function of regenerated peripheral nerve fibers and reinnervated mechanoreceptors may differentially influence recovery of sensory modalities. Touch was affected by the number and function of regenerated fibers and mechanoreceptors. In contrast, tactile gnosis depends on the input and plasticity of the central nervous system (CNS), which may explain the absence of a direct relation between electrophysiological parameters and poor recovery. Dispersed maturation of sensory nerve fibers with desynchronized inputs to the CNS also contributes to the poor recovery of tactile gnosis. Ann Neurol 2017. Ann Neurol 2017;82:940-950.",
keywords = "Action Potentials, Adult, Female, Follow-Up Studies, Humans, Male, Mechanoreceptors, Median Nerve, Middle Aged, Nerve Fibers, Nerve Regeneration, Peripheral Nerve Injuries, Physical Stimulation, Sensation, Touch, Ulnar Nerve, Young Adult, Journal Article",
author = "Christian Krarup and Birgitta Ros{\'e}n and Michel Boeckstyns and {Ibsen S{\o}rensen}, Allan and G{\"o}ran Lundborg and Mihai Moldovan and Archibald, {Simon J}",
note = "{\textcopyright} 2017 American Neurological Association.",
year = "2017",
doi = "10.1002/ana.25102",
language = "English",
volume = "82",
pages = "940--950",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Sensation, mechanoreceptor, and nerve fiber function after nerve regeneration

AU - Krarup, Christian

AU - Rosén, Birgitta

AU - Boeckstyns, Michel

AU - Ibsen Sørensen, Allan

AU - Lundborg, Göran

AU - Moldovan, Mihai

AU - Archibald, Simon J

N1 - © 2017 American Neurological Association.

PY - 2017

Y1 - 2017

N2 - OBJECTIVE: Sensation is essential for recovery after peripheral nerve injury. However, the relationship between sensory modalities and function of regenerated fibers is uncertain. We have investigated the relationships between touch threshold, tactile gnosis, and mechanoreceptor and sensory fiber function after nerve regeneration.METHODS: Twenty-one median or ulnar nerve lesions were repaired by a collagen nerve conduit or direct suture. Quantitative sensory hand function and sensory conduction studies by near-nerve technique, including tactile stimulation of mechanoreceptors, were followed for 2 years, and results were compared to noninjured hands.RESULTS: At both repair methods, touch thresholds at the finger tips recovered to 81 ± 3% and tactile gnosis only to 20 ± 4% (p < 0.001) of control. The sensory nerve action potentials (SNAPs) remained dispersed and areas recovered to 23 ± 2% and the amplitudes only to 7 ± 1% (P < 0.001). The areas of SNAPs after tactile stimulation recovered to 61 ± 11% and remained slowed. Touch sensation correlated with SNAP areas (p < 0.005) and was negatively related to the prolongation of tactile latencies (p < 0.01); tactile gnosis was not related to electrophysiological parameters.INTERPRETATION: The recovered function of regenerated peripheral nerve fibers and reinnervated mechanoreceptors may differentially influence recovery of sensory modalities. Touch was affected by the number and function of regenerated fibers and mechanoreceptors. In contrast, tactile gnosis depends on the input and plasticity of the central nervous system (CNS), which may explain the absence of a direct relation between electrophysiological parameters and poor recovery. Dispersed maturation of sensory nerve fibers with desynchronized inputs to the CNS also contributes to the poor recovery of tactile gnosis. Ann Neurol 2017. Ann Neurol 2017;82:940-950.

AB - OBJECTIVE: Sensation is essential for recovery after peripheral nerve injury. However, the relationship between sensory modalities and function of regenerated fibers is uncertain. We have investigated the relationships between touch threshold, tactile gnosis, and mechanoreceptor and sensory fiber function after nerve regeneration.METHODS: Twenty-one median or ulnar nerve lesions were repaired by a collagen nerve conduit or direct suture. Quantitative sensory hand function and sensory conduction studies by near-nerve technique, including tactile stimulation of mechanoreceptors, were followed for 2 years, and results were compared to noninjured hands.RESULTS: At both repair methods, touch thresholds at the finger tips recovered to 81 ± 3% and tactile gnosis only to 20 ± 4% (p < 0.001) of control. The sensory nerve action potentials (SNAPs) remained dispersed and areas recovered to 23 ± 2% and the amplitudes only to 7 ± 1% (P < 0.001). The areas of SNAPs after tactile stimulation recovered to 61 ± 11% and remained slowed. Touch sensation correlated with SNAP areas (p < 0.005) and was negatively related to the prolongation of tactile latencies (p < 0.01); tactile gnosis was not related to electrophysiological parameters.INTERPRETATION: The recovered function of regenerated peripheral nerve fibers and reinnervated mechanoreceptors may differentially influence recovery of sensory modalities. Touch was affected by the number and function of regenerated fibers and mechanoreceptors. In contrast, tactile gnosis depends on the input and plasticity of the central nervous system (CNS), which may explain the absence of a direct relation between electrophysiological parameters and poor recovery. Dispersed maturation of sensory nerve fibers with desynchronized inputs to the CNS also contributes to the poor recovery of tactile gnosis. Ann Neurol 2017. Ann Neurol 2017;82:940-950.

KW - Action Potentials

KW - Adult

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Mechanoreceptors

KW - Median Nerve

KW - Middle Aged

KW - Nerve Fibers

KW - Nerve Regeneration

KW - Peripheral Nerve Injuries

KW - Physical Stimulation

KW - Sensation

KW - Touch

KW - Ulnar Nerve

KW - Young Adult

KW - Journal Article

U2 - 10.1002/ana.25102

DO - 10.1002/ana.25102

M3 - Journal article

C2 - 29156496

VL - 82

SP - 940

EP - 950

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 6

ER -

ID: 52625979