Senescence rates in patients with end-stage renal disease: a critical appraisal of the Gompertz model

J J E Koopman, M P Rozing, Ada Kramer, D J de Jager, D Ansell, J M J De Meester, K G Prütz, P Finne, J G Heaf, R Palsson, R Kramar, K J Jager, F W Dekker, R G J Westendorp

20 Citationer (Scopus)

Abstract

The most frequently used model to describe the exponential increase in mortality rate over age is the Gompertz equation. Logarithmically transformed, the equation conforms to a straight line, of which the slope has been interpreted as the rate of senescence. Earlier, we proposed the derivative function of the Gompertz equation as a superior descriptor of senescence rate. Here, we tested both measures of the rate of senescence in a population of patients with end-stage renal disease. It is clinical dogma that patients on dialysis experience accelerated senescence, whereas those with a functional kidney transplant have mortality rates comparable to the general population. Therefore, we calculated the age-specific mortality rates for European patients on dialysis (n=274 221; follow-up=594 767 person-years), for European patients with a functioning kidney transplant (n=61 286; follow-up=345 024 person-years), and for the general European population. We found higher mortality rates, but a smaller slope of logarithmic mortality curve for patients on dialysis compared with both patients with a functioning kidney transplant and the general population (P
OriginalsprogEngelsk
TidsskriftAging Cell
Vol/bind10
Udgave nummer2
Sider (fra-til)233-8
Antal sider6
ISSN1474-9718
DOI
StatusUdgivet - 2011

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