Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Semen quality in patients with pituitary disease and adult-onset hypogonadotropic hypogonadism

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Genotype-phenotype associations in PPGLs in 59 patients with variants in SDHX genes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Levels of endocrine-disrupting chemicals are associated with changes in the peri-pubertal epigenome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Sacubitril/valsartan increases postprandial gastrin and cholecystokinin in plasma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Role of fasting duration and weekday in incretin and glucose regulation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. No detectable effect of a type 2 diabetes-associated TCF7L2 genotype on the incretin effect

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. DIAGNOSIS OF ENDOCRINE DISEASE: Sex steroid action in adolescence: too much, too little; too early, too late

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Trend of Menarcheal Age among Korean Girls

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Sex differences in acromegaly at diagnosis: A nationwide cohort study and meta-analysis of the literature

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Adrenal insufficiency in kidney transplant patients during low-dose prednisolone therapy: a cross-sectional case-control study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Age-related changes in human Leydig cell status

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: Gonadotropins (luteinizing hormone (LH) and follicle-stimulating hormone (FSH)) are released from the pituitary gland and stimulate Leydig cells to produce testosterone and initiates spermatogenesis. Little is known about how and when the deterioration of semen quality occurs in patients with adult-onset gonadotropin insufficiency.

DESIGN AND METHODS: A retrospective study comprising 20 testosterone-deficient men (median age, 29 years) with acquired pituitary disease who delivered semen for cryopreservation before initiation of testosterone therapy. Semen variables and hormone concentrations were compared to those of young healthy men (n = 340).

RESULTS: Thirteen of 20 patients (65%) and 82% of controls had total sperm counts above 39 million and progressive motile spermatozoa above 32% (P = 0.05). For the individual semen variables, there were no significant differences in semen volume (median (intraquartile range) 3.0 (1.3-6.8) vs 3.2 (2.3-4.3) mL, P = 0.47), sperm concentration 41 (11-71) vs 43 (22-73) mill/mL (P = 0.56) or total sperm counts (P = 0.66). One patient had azoospermia. Patients vs controls had lower serum testosterone 5.4 (2.2-7.6) vs 19.7 (15.5-24.5) nmol/L (P = 0.001), calculated free testosterone (cfT) 145 (56-183) vs 464 (359-574) pmol/L (P < 0.001), LH 1.5 (1.1-2.1) vs 3.1 (2.3-4.0) U/L (P = 0.002) and inhibin b (P < 0.001). Levels of FSH were similar (P = 0.63). Testosterone/LH ratio and cfT/LH ratio were reduced in patients (both P < 0.001).

CONCLUSIONS: Despite Leydig cell insufficiency in patients with acquired pituitary insufficiency, the majority presented with normal semen quality based on the determination of the number of progressively motile spermatozoa. In addition, the data suggest reduced LH bioactivity in patients with pituitary insufficiency.

OriginalsprogEngelsk
TidsskriftEndocrine Connections
Vol/bind7
Udgave nummer4
Sider (fra-til)523-533
Antal sider11
ISSN2049-3614
DOI
StatusUdgivet - apr. 2018

ID: 53620714