TY - JOUR
T1 - Selected testosterone-related diseases in women who have given birth to a child with infantile autism
AU - Mouridsen, Svend-Erik
AU - Rich, Bente
AU - Isager, Torben
N1 - Keywords: Adult; Age Factors; Aged; Aged, 80 and over; Autistic Disorder; Breast Neoplasms; Child; Child of Impaired Parents; Child, Preschool; Denmark; Female; Follow-Up Studies; Genital Neoplasms, Female; Humans; Male; Middle Aged; Mothers; Ovarian Neoplasms; Pregnancy; Prenatal Exposure Delayed Effects; Prevalence; Sex Distribution; Testosterone; Uterine Neoplasms
PY - 2009
Y1 - 2009
N2 - AIM: The objective of the current study was to compare the prevalence of three testosterone-related cancer diseases in the mothers of 111 individuals diagnosed as children with infantile autism (IA) with a matched comparison group of mothers of 330 children from the general population. METHOD: All mothers were screened through the nationwide Danish National Hospital Register. We inquired about breast-, uterine-, and ovarian cancer diseases during an observation period of 27 years. RESULTS: At follow up a similar proportion of case and control mothers had a diagnosis of any cancer disease: 6.3% vs 8.5%. In addition, no single cancer disease was significantly more frequent among mothers of children with IA. CONCLUSION: Our study provides no support for an (eventually androgen-mediated) increased rate of cancer in mothers of persons with IA.
AB - AIM: The objective of the current study was to compare the prevalence of three testosterone-related cancer diseases in the mothers of 111 individuals diagnosed as children with infantile autism (IA) with a matched comparison group of mothers of 330 children from the general population. METHOD: All mothers were screened through the nationwide Danish National Hospital Register. We inquired about breast-, uterine-, and ovarian cancer diseases during an observation period of 27 years. RESULTS: At follow up a similar proportion of case and control mothers had a diagnosis of any cancer disease: 6.3% vs 8.5%. In addition, no single cancer disease was significantly more frequent among mothers of children with IA. CONCLUSION: Our study provides no support for an (eventually androgen-mediated) increased rate of cancer in mothers of persons with IA.
U2 - 10.1111/j.1440-1819.2009.01997.x
DO - 10.1111/j.1440-1819.2009.01997.x
M3 - Journal article
C2 - 19659562
SN - 1440-1819
VL - 63
SP - 586
EP - 590
JO - Psychiatry and Clinical Neurosciences
JF - Psychiatry and Clinical Neurosciences
IS - 4
ER -