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Secular trends in the incidence and prevalence of gout in Denmark from 1995 to 2015: a nationwide register-based study

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@article{0398ecd59ea44e7da7c58f64d3b5312d,
title = "Secular trends in the incidence and prevalence of gout in Denmark from 1995 to 2015: a nationwide register-based study",
abstract = "OBJECTIVE: To investigate temporal trends in the incidence and prevalence of gout in the adult Danish population.METHODS: Using the nationwide Danish National Patient Registry, we calculated the number of incident gout patients (per 100 000 person-years) within each 1 year period from 1995 to 2015 and the prevalence of gout in 2000 and 2015. Further, we calculated age- and gender-specific incidence rates of gout from 1995 to 2015.RESULTS: We identified a total of 45 685 incident gout patients (72.9{\%} males) with a mean age of 65 years (s.d. 16) at diagnosis. In both genders, an increase in age-standardized incidence rates was observed from 32.3/100 000 (95{\%} CI 30.7, 33.9) in 1995 to 57.5/100 000 (95{\%} CI 55.6, 59.5) in 2015 (P < 0.001). Similar trends were observed for 8950 cases diagnosed in rheumatology departments. We likewise observed an increase in the prevalence of gout from 0.29{\%} (95{\%} CI 0.29, 0.30) in 2000 to 0.68{\%} (95{\%} CI 0.68, 0.69) in 2015.CONCLUSIONS: The annual incidence rate of gout increased by almost 80{\%} in Denmark between 1995 and 2015. The prevalence increased by nearly 130{\%} between 2000 and 2015. Reasons for this are unknown but may include an increase in risk factors (e.g. obesity, diabetes mellitus), longer life expectancy and increased awareness of the disease among patients and/or health professionals.",
keywords = "Crystal arthropathy, Epidemiology, Gout, Incidence, Prevalence",
author = "Kristian Zobbe and Daniel Prieto-Alhambra and Ren{\'e} Cordtz and Pil H{\o}jgaard and Hindrup, {Jens Sk{\o}t} and Kristensen, {Lars Erik} and Lene Dreyer",
note = "COPECARE",
year = "2019",
month = "5",
day = "1",
doi = "10.1093/rheumatology/key390",
language = "English",
volume = "58",
pages = "836--839",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Secular trends in the incidence and prevalence of gout in Denmark from 1995 to 2015

T2 - a nationwide register-based study

AU - Zobbe, Kristian

AU - Prieto-Alhambra, Daniel

AU - Cordtz, René

AU - Højgaard, Pil

AU - Hindrup, Jens Skøt

AU - Kristensen, Lars Erik

AU - Dreyer, Lene

N1 - COPECARE

PY - 2019/5/1

Y1 - 2019/5/1

N2 - OBJECTIVE: To investigate temporal trends in the incidence and prevalence of gout in the adult Danish population.METHODS: Using the nationwide Danish National Patient Registry, we calculated the number of incident gout patients (per 100 000 person-years) within each 1 year period from 1995 to 2015 and the prevalence of gout in 2000 and 2015. Further, we calculated age- and gender-specific incidence rates of gout from 1995 to 2015.RESULTS: We identified a total of 45 685 incident gout patients (72.9% males) with a mean age of 65 years (s.d. 16) at diagnosis. In both genders, an increase in age-standardized incidence rates was observed from 32.3/100 000 (95% CI 30.7, 33.9) in 1995 to 57.5/100 000 (95% CI 55.6, 59.5) in 2015 (P < 0.001). Similar trends were observed for 8950 cases diagnosed in rheumatology departments. We likewise observed an increase in the prevalence of gout from 0.29% (95% CI 0.29, 0.30) in 2000 to 0.68% (95% CI 0.68, 0.69) in 2015.CONCLUSIONS: The annual incidence rate of gout increased by almost 80% in Denmark between 1995 and 2015. The prevalence increased by nearly 130% between 2000 and 2015. Reasons for this are unknown but may include an increase in risk factors (e.g. obesity, diabetes mellitus), longer life expectancy and increased awareness of the disease among patients and/or health professionals.

AB - OBJECTIVE: To investigate temporal trends in the incidence and prevalence of gout in the adult Danish population.METHODS: Using the nationwide Danish National Patient Registry, we calculated the number of incident gout patients (per 100 000 person-years) within each 1 year period from 1995 to 2015 and the prevalence of gout in 2000 and 2015. Further, we calculated age- and gender-specific incidence rates of gout from 1995 to 2015.RESULTS: We identified a total of 45 685 incident gout patients (72.9% males) with a mean age of 65 years (s.d. 16) at diagnosis. In both genders, an increase in age-standardized incidence rates was observed from 32.3/100 000 (95% CI 30.7, 33.9) in 1995 to 57.5/100 000 (95% CI 55.6, 59.5) in 2015 (P < 0.001). Similar trends were observed for 8950 cases diagnosed in rheumatology departments. We likewise observed an increase in the prevalence of gout from 0.29% (95% CI 0.29, 0.30) in 2000 to 0.68% (95% CI 0.68, 0.69) in 2015.CONCLUSIONS: The annual incidence rate of gout increased by almost 80% in Denmark between 1995 and 2015. The prevalence increased by nearly 130% between 2000 and 2015. Reasons for this are unknown but may include an increase in risk factors (e.g. obesity, diabetes mellitus), longer life expectancy and increased awareness of the disease among patients and/or health professionals.

KW - Crystal arthropathy

KW - Epidemiology

KW - Gout

KW - Incidence

KW - Prevalence

U2 - 10.1093/rheumatology/key390

DO - 10.1093/rheumatology/key390

M3 - Journal article

VL - 58

SP - 836

EP - 839

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - 5

ER -

ID: 58097528