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Region Hovedstaden - en del af Københavns Universitetshospital
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Searchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms

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  • Yong-Ming Wang
  • Xin-Lu Cai
  • Rui-Ting Zhang
  • Yi Wang
  • Kristoffer Hougaard Madsen
  • Thomas Alrik Sørensen
  • Arne Møller
  • Eric F C Cheung
  • Raymond C K Chan
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INTRODUCTION: Investigating obsessive-compulsive symptoms in subclinical populations provides a useful framework for understanding the early development of obsessive-compulsive spectrum disorders. The present study aimed to apply searchlight classification analysis on resting-state functional magnetic resonance imaging data to identify potential brain markers in subclinical individuals with obsessive-compulsive symptoms.

METHODS: In this observational study, 40 college students with high obsessive-compulsive symptom scores and 40 with low obsessive-compulsive symptom scores were recruited from universities in China. We conducted searchlight classification and comparison analysis between the two groups based on Amplitude of Low Frequency Fluctuation (ALFF), fraction ALFF (fALFF) and resting-state functional connectivity using searchlight classification.

RESULTS: We found that the highest accuracy rate in differentiating between the two groups was 85.00%. Significant discriminating features included the ALFF of the left medial superior frontal gyrus and the functional connectivity between the right thalamus and the bilateral medial superior frontal gyrus, and the right putamen, as well as the functional connectivity between the left caudate and the right insula.

CONCLUSIONS: These findings highlight the specific and distinguishing brain functional abnormalities associated with obsessive-compulsive symptoms.

OriginalsprogEngelsk
TidsskriftCognitive neuropsychiatry
Vol/bind24
Udgave nummer5
Sider (fra-til)322-334
Antal sider13
ISSN1354-6805
DOI
StatusUdgivet - sep. 2019

ID: 57863981