Sealing effect of hydroxyapatite coating: A 12-month study in canines

O. Rahbek*, S. Overgaard, T. B. Jensen, K. Bendix, K. Soballe

*Corresponding author af dette arbejde
37 Citationer (Scopus)

Abstract

This study addresses the clinical problems regarding access of wear debris to the bone-implant interface and the possible dissemination of polyethylene (PE) particles to distant organs. We inserted two implants into each knee of 7 dogs allowing access of joint fluid to the bone-implant interface with a 0.75 mm initial gap around the implant. Hydroxyapatite (HA)-coated and non-coated (Ti) titanium alloy implants were randomly allocated to each distal femoral condyle. PE particles were repeatedly injected into the right knee joint 3 weeks after surgery for a period of 49 weeks, while only vehicle was injected into the left knee joint. We found huge amounts of PE particles mainly in the bone-implant interface around Ti implants. Infiltration of mononuclear inflammatory cells was present around 3 of 7 Ti implants in relation to PE particles. HA implants had approximately 70% bone ongrowth. In contrast, no bone ongrowth was seen on any Ti implants, all being surrounded by a fibrous membrane. The number of PE particles was evaluated semi-quantitatively. More PE particles were found around Ti implants than with HA implants (p < 0.002). Specimens from iliac lymph nodes, liver, spleen and lung were examined and showed dissemination of PE particles only in regional lymph nodes.

OriginalsprogEngelsk
TidsskriftActa Orthopaedica Scandinavica
Vol/bind71
Udgave nummer6
Sider (fra-til)563-573
Antal sider11
ISSN0001-6470
DOI
StatusUdgivet - 2000

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