Screening of 1331 Danish breast and/or ovarian cancer families identified 40 novel BRCA1 and BRCA2 mutations

Keyphrases

• Ovarian Cancer 100%
• Breast 100%
• Missense mutation 100%
• BRCA2 mutation 100%
• BRCA mutation 100%
• Cancer Families 100%
• BRCA2 75%
• Breast Cancer Susceptibility Gene 1 (BRCA1) 75%
• Synonymous Variant 50%
• BRCA1, BRCA2 50%
• Variants of Uncertain Significance 50%
• Intronic Variant 50%
• Denmark 25%
• High Risk 25%
• Breast Cancer 25%
• Cause of Disease 25%
• Novel Variants 25%
• Mutation Screening 25%
• In Silico Analysis 25%
• Sequence Variation 25%
• Direct Sequencing 25%
• Nineteen 25%
• In Silico 25%
• Pre-screening 25%
• Denaturing High-performance Liquid Chromatography (DHPLC) 25%
• BRCA1 Gene 25%
• BRCA2 Gene 25%
• Frameshift 25%
• Germline mutation 25%
• Nonsense 25%
• Ovarian Cancer Patients 25%
• Mutation Spectrum 25%
• Tumor Suppressor Gene 25%
• High-resolution Melting 25%
• Frameshift mutation 25%
• Novel Sequences 25%
• Mutational Screening 25%

Biochemistry, Genetics and Molecular Biology

• BRCA2 100%
• BRCA1 100%
• Missense Mutation 57%
• Computer Model 28%
• Tumor Suppressor Gene 28%
• Germline Mutation 14%
• Melting Point 14%