TY - JOUR
T1 - Screening for Down's syndrome using an iso-risk curve based on maternal age and serum alpha-fetoprotein level
AU - Tabor, A
AU - Larsen, S O
AU - Nielsen, J
AU - Nielsen, J
AU - Philip, J
AU - Pilgaard, B
AU - Videbech, P
AU - Nørgaard-Pedersen, B
PY - 1987/7
Y1 - 1987/7
N2 - On the basis of the significantly different distributions of maternal serum alpha-fetoprotein (AFP) levels in 86 pregnancies associated with fetal Down's syndrome and in 2018 unaffected pregnancies, an iso-risk curve for Down's syndrome was constructed. An iso-risk curve shows, for women of all ages, which combinations of maternal age and level of maternal serum AFP result in the same risk of carrying a fetus with Down's syndrome. A 1:400 risk of Down's syndrome, corresponding to the risk of a 35-year-old woman, was chosen as the lowest risk indicating referral for amniocentesis. If all women, irrespective of their age, are offered amniocentesis, when their risk of carrying a Down's syndrome fetus is 1:400 or higher, 53% of the affected fetuses can be detected as compared with 28% of the affected fetuses diagnosed at present in women above 35 years of age.
AB - On the basis of the significantly different distributions of maternal serum alpha-fetoprotein (AFP) levels in 86 pregnancies associated with fetal Down's syndrome and in 2018 unaffected pregnancies, an iso-risk curve for Down's syndrome was constructed. An iso-risk curve shows, for women of all ages, which combinations of maternal age and level of maternal serum AFP result in the same risk of carrying a fetus with Down's syndrome. A 1:400 risk of Down's syndrome, corresponding to the risk of a 35-year-old woman, was chosen as the lowest risk indicating referral for amniocentesis. If all women, irrespective of their age, are offered amniocentesis, when their risk of carrying a Down's syndrome fetus is 1:400 or higher, 53% of the affected fetuses can be detected as compared with 28% of the affected fetuses diagnosed at present in women above 35 years of age.
KW - Adult
KW - Down Syndrome/diagnosis
KW - Female
KW - Fetal Diseases/diagnosis
KW - Humans
KW - Maternal Age
KW - Pregnancy
KW - Pregnancy, High-Risk
KW - Prenatal Diagnosis/methods
KW - Risk
KW - alpha-Fetoproteins/analysis
M3 - Journal article
C2 - 2441737
SN - 0306-5456
VL - 94
SP - 636
EP - 642
JO - British Journal of Obstetrics and Gynaecology
JF - British Journal of Obstetrics and Gynaecology
IS - 7
ER -