Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Screening for autologous blood transfusions

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. The Association Between Self-Rated Fitness and Cardiorespiratory Fitness in Adults

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Maximal Fat Oxidation is Related to Performance in an Ironman Triathlon

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Urine and serum concentrations of inhaled and oral terbutaline

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Urine concentrations of repetitive doses of inhaled salbutamol

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Targeted Rhesus immunoglobulin for RhD negative women undergoing an induced abortion: a clinical pilot study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Blood group genotyping of blood donors: validation of a highly accurate routine method

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. GPDPLQ1237-A Type II Collagen Neo-Epitope Biomarker of Osteoclast- and Inflammation-Derived Cartilage Degradation in vitro

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
The ratio between the amount of hemoglobin in the mature erythrocyte population and the reticulocytes (RBCHb:RetHb ratio) has previously been suggested as a marker to screen for EPO-abuse. We speculated that the reinfusion of blood would lead to a marked increase in this ratio, making it a valuable parameter in the screening for autologous blood doping. Three bags of blood (approximately 201+/-11 g of Hb) were withdrawn from 16 males and stored at either -80 degrees C (-80 T, n=8) or +4 degrees C (+4 T, n=8) and reinfused 10 weeks or 4 weeks later, respectively. Seven subjects served as controls. Different erythrocyte parameters were measured on a hematological analyzer serially throughout and during a 4 week wash-out period. By using RBCHb:RetHb ratio cut-off limits of 145.7 (1:100) ('suspicious') and 182.9 (1:1000) ('positive'), 35.4% (-80 T) and 19.6% (+4 T) of all samples obtained during a 4 week wash-out period were identified as 'suspicious', and 18.8% (-80 T) and 4.3% (+4 T) as 'positive'. In total, 7 out of 16 (43.8%) subjects had at least one sample exceeding 182.9. Compared to the currently used indirect parameters, the RBCHb:RetHb ratio is the best indicator of autologous blood doping after reinfusion, and the parameter could be used in a testing setting, once stability validation has been performed.
OriginalsprogEngelsk
TidsskriftInternational Journal of Sports Medicine
Vol/bind30
Udgave nummer4
Sider (fra-til)285-92
Antal sider8
ISSN0172-4622
DOI
StatusUdgivet - 1 apr. 2009

ID: 32358067