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Region Hovedstaden - en del af Københavns Universitetshospital
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Schizophrenia Spectrum Disorders in a Danish 22q11.2 Deletion Syndrome Cohort Compared to the Total Danish Population-A Nationwide Register Study

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DOI

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  1. Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

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  2. Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors

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  3. Pleiotropy between language impairment and broader behavioral disorders-an investigation of both common and rare genetic variants

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OBJECTIVE: Cross-sectional studies have shown associations between 22q11.2 deletion syndrome and schizophrenia. However, large-scale prospective studies have been lacking. We, therefore, conducted the first large-scale population based study on the risk of being diagnosed with schizophrenia in persons identified with 22q11.2 deletion syndrome.

METHODS: Danish nationwide registers were linked to establish a cohort consisting of all Danish citizens born during 1955-2004 and the cohort was followed from January 1, 1994 until December 31, 2013. Data were analyzed using survival analyses and adjusted for calendar year, age, sex, and parental mental health history.

RESULTS: A total of 156 individuals with 22q11.2 deletion syndrome were identified, out of which 6 individuals were diagnosed with schizophrenia spectrum disorders following identification with 22q11 deletion syndrome. Identified carriers of 22q11.2 deletion had an 8.13(95% CI: 3.65-18.09) fold increased risk of schizophrenia spectrum disorder.

CONCLUSIONS: Carriers of a 22q11.2 deletion who had been clinically identified had a highly increased risk of schizophrenia spectrum disorders.

OriginalsprogEngelsk
TidsskriftSchizophrenia Bulletin
Vol/bind42
Udgave nummer3
Sider (fra-til)824-831
ISSN0586-7614
DOI
StatusUdgivet - maj 2016

ID: 45976848