Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene

Mirjana Tosic, Jurg Ott, Sandra Barral, Pierre Bovet, Patricia Deppen, Fulvia Gheorghita, Marie-Louise Matthey, Josef Parnas, Martin Preisig, Michael Saraga, Alessandra Solida, Sally Timm, August G Wang, Thomas Werge, Michel Cuénod, Kim Quang Do

209 Citationer (Scopus)

Abstract

Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.
OriginalsprogEngelsk
TidsskriftAmerican Journal of Human Genetics
Vol/bind79
Udgave nummer3
Sider (fra-til)586-92
Antal sider7
ISSN0002-9297
DOI
StatusUdgivet - 1 sep. 2006

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