Abstract
Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.
Originalsprog | Engelsk |
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Tidsskrift | American Journal of Human Genetics |
Vol/bind | 79 |
Udgave nummer | 3 |
Sider (fra-til) | 586-92 |
Antal sider | 7 |
ISSN | 0002-9297 |
DOI | |
Status | Udgivet - 1 sep. 2006 |