Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

SATB1 in Malignant T Cells

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Racial/Ethnic Differences in Incidence and Persistence of Childhood Atopic Dermatitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Incidence and Risk of Inflammatory Bowel Disease in Patients with Psoriasis-A Nationwide 20-Year Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Increased Suicide Risk in Patients with Hidradenitis Suppurativa

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Germline Variation at CDKN2A and Associations with Nevus Phenotypes among Members of Melanoma Families

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Research Techniques Made Simple: Choosing Appropriate Statistical Methods for Clinical Research

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Chimeric antigen receptor-T-cellebehandling

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Inflammation induced PD-L1-specific T cells

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Expression and function of Kv1.3 channel in malignant T cells in Sézary syndrome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Correction: Tumour-reactive T cell subsets in the microenvironment of ovarian cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Cancerimmunterapi til behandling af hæmatologisk cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Simon Fredholm
  • Andreas Willerslev-Olsen
  • Özcan Met
  • Linda Kubat
  • Maria Gluud
  • Sarah L Mathiasen
  • Christina Friese
  • Edda Blümel
  • David L Petersen
  • Tengpeng Hu
  • Claudia Nastasi
  • Lise M Lindahl
  • Terkild B Buus
  • Thorbjørn Krejsgaard
  • Mariusz A Wasik
  • Katharina L Kopp
  • Sergei B Koralov
  • Jenny L Persson
  • Charlotte M Bonefeld
  • Carsten Geisler
  • Anders Woetmann
  • Lars Iversen
  • Jürgen C Becker
  • Niels Ødum
Vis graf over relationer

Deficient expression of SATB1 hampers thymocyte development and results in inept T-cell lineages. Recent data implicate dysregulated SATB1 expression in the pathogenesis of mycosis fungoides, the most frequent variant of cutaneous T-cell lymphoma. Here, we report on a disease stage-associated decrease of SATB1 expression and an inverse expression of STAT5 and SATB1 in situ. STAT5 inhibited SATB1 expression through induction of microRNA-155. Decreased SATB1 expression triggered enhanced expression of IL-5 and IL-9 (but not IL-6 and IL-32), whereas increased SATB1 expression had the opposite effect, indicating that the microRNA-155 target SATB1 is a repressor of IL-5 and IL-9 in malignant T cells. In accordance, inhibition of STAT5 and its upstream activator JAK3 triggered increased SATB1 expression and a concomitant suppression of IL-5 and IL-9 expression in malignant T cells. In conclusion, we provide a mechanistic link between the proto-oncogenic JAK3/STAT5/microRNA-155 pathway, SATB1, and cytokines linked to CTCL severity and progression, indicating that SATB1 dysregulation is involved in cutaneous T-cell lymphoma pathogenesis.

OriginalsprogEngelsk
TidsskriftThe Journal of investigative dermatology
Vol/bind138
Udgave nummer8
Sider (fra-til)1805-1815
Antal sider11
ISSN0022-202X
DOI
StatusUdgivet - aug. 2018

ID: 56258927