Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

SARS-CoV-2 infection among patients with haematological disorders: Severity and one-month outcome in 66 Danish patients in a nationwide cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Reference values for the EORTC QLQ-C30 in patients with advanced stage Hodgkin Lymphoma and in Hodgkin Lymphoma survivors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Vitamin E and acute graft-versus-host disease after myeloablative allogeneic hematopoietic cell transplantation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Real-World Outcomes for 205 Patients with Chronic Lymphocytic Leukemia Treated with Ibrutinib

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Unexpected, isolated activated partial thromboplastin time prolongation: A practical mini-review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Response to Aviv et al

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. Prevalence and association with birth outcomes of low Vitamin D levels among pregnant women living with HIV

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The Danish HIV Birth Cohort (DHBC) - a nationwide, prospective cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVES: Patients with haematological disorders may be particularly vulnerable to respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, this is unknown.

METHODS: We conducted a prospective, nationwide study including 66 patients in follow-up at Danish haematology departments with a malignant or non-malignant haematological disorder and with verified SARS-CoV-2 infection. Outcomes were intensive care unit (ICU) admission and one-month survival rate.

RESULTS: Mean age was 66.7 years, 60.6% were males, 90.9% had comorbidity, and 13.6% had a BMI ≥ 30. The most frequent diagnoses were chronic lymphocytic leukaemia/lymphoma (47.0%), multiple myeloma (16.7%) and acute leukaemia/myelodysplastic syndrome (AL/MDS) (12.1%). Treatment for the haematological disease was ongoing in 59.1% of cases. Neutropenia was present in 6.5%, lymphopenia in 46.6% and hypogammaglobulinaemia in 26.3%. The SARS-CoV-2 infection was mild in 50.0%, severe in 36.4% and critical in 13.6%. After one month, 21.2% had been admitted to ICU, and 24.2% died. Mortality was highest in older patients, patients with severe/critical SARS-CoV-2 infection, high comorbidity score or high performance status score, purine analogue treatment and with AL/MDS. Although older patients and patients with comorbidities had the highest mortality rates, mortality was considerable among all haematological patients.

CONCLUSION: Haematological patients with SARS-CoV-2 infection has a severe clinical course.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Haematology
Vol/bind106
Udgave nummer1
Sider (fra-til)72-81
Antal sider10
ISSN0902-4441
DOI
StatusUdgivet - jan. 2021

Bibliografisk note

© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

ID: 62072745