Abstrakt
Penicillin is the drug of choice for treatment of community-acquired pneumonia (CAP) in Denmark. The primary determinant for therapeutic activity of penicillin is ''penicillin time'' (T>MIC), i.e. time with penicillin concentration above minimum inhibitory concentration. Eradication of S. pneumoniae requires T>MIC above 40-50%. The second determinant for therapeutic activity is the ratio between maximum penicillin concentration in serum and MIC (Cmax/MIC). Considering penicillin pharmacokinetics, intravenous penicillin 2 million units four times a day is recommended as empirical treatment of CAP.
| Bidragets oversatte titel | Treatment of community-acquired pneumonia--treatment |
|---|---|
| Originalsprog | Dansk |
| Tidsskrift | Ugeskrift for Laeger |
| Vol/bind | 170 |
| Udgave nummer | 3 |
| Sider (fra-til) | 127-30 |
| Antal sider | 4 |
| ISSN | 0041-5782 |
| Status | Udgivet - 14 jan. 2008 |
| Udgivet eksternt | Ja |
Emneord
- Community-Acquired Infections
- Humans
- Injections, Intravenous
- Microbial Sensitivity Tests
- Penicillins
- Pneumonia, Pneumococcal
- Streptococcus pneumoniae