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Salt Reduction Intervention in Families Investigating Metabolic, Behavioral and Health Effects of Targeted Intake Reductions: Study Protocol for a Four Months Three-Armed, Randomized, Controlled "Real-Life" Trial

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@article{31b581aa92db466cbe59b86eae7f008a,
title = "Salt Reduction Intervention in Families Investigating Metabolic, Behavioral and Health Effects of Targeted Intake Reductions: Study Protocol for a Four Months Three-Armed, Randomized, Controlled {"}Real-Life{"} Trial",
abstract = "Reductions in salt intake have the potential to markedly improve population health at low cost. Real life interventions that explore the feasibility and health effects of a gradual salt reduction lasting at least four weeks are required. The randomized controlled SalT Reduction InterVEntion (STRIVE) trial was developed to investigate the metabolic, behavioral and health effects of four months of consuming gradually salt reduced bread alone or in combination with dietary counselling. This paper describes the rationale and methods of STRIVE. Aiming at 120 healthy families, participants were recruited in February 2018 from the Danish Capital Region and randomly allocated into: (A) Salt reduced bread; (B) Salt reduced bread and dietary counseling; (C) Standard bread. Participants were examined before the intervention and at four months follow-up. Primary outcome is change in salt intake measured by 24 h urine. Secondary outcomes are change in urine measures of potassium and sodium/ potassium ratio, blood pressure, plasma lipids, the renin-angiotensin system, the sympathetic nervous response, dietary intake as well as salt taste sensitivity and preferences. The results will qualify mechanisms affected during a gradual reduction in salt intake in compliance with the current public health recommendations.",
keywords = "Cardiovascular consequences, Gradual salt reduction, Randomized controlled trial, Sodium potassium ratio, Statistical analysis plan",
author = "Bjoernsbo, {Kirsten Schroll} and Riis, {Nanna Louise} and Andreasen, {Anne Helms} and Janne Petersen and {Dahl Lassen}, Anne and Ellen Trolle and Frederiksen, {Amalie Kruse Sigersted} and Munk, {Jens Kristian} and Ulla Toft",
year = "2019",
month = "9",
day = "21",
doi = "10.3390/ijerph16193532",
language = "English",
volume = "16",
journal = "International Journal of Environmental Research and Public Health",
issn = "1661-7827",
publisher = "Molecular Diversity Preservation International (M D P I)",
number = "19",

}

RIS

TY - JOUR

T1 - Salt Reduction Intervention in Families Investigating Metabolic, Behavioral and Health Effects of Targeted Intake Reductions

T2 - Study Protocol for a Four Months Three-Armed, Randomized, Controlled "Real-Life" Trial

AU - Bjoernsbo, Kirsten Schroll

AU - Riis, Nanna Louise

AU - Andreasen, Anne Helms

AU - Petersen, Janne

AU - Dahl Lassen, Anne

AU - Trolle, Ellen

AU - Frederiksen, Amalie Kruse Sigersted

AU - Munk, Jens Kristian

AU - Toft, Ulla

PY - 2019/9/21

Y1 - 2019/9/21

N2 - Reductions in salt intake have the potential to markedly improve population health at low cost. Real life interventions that explore the feasibility and health effects of a gradual salt reduction lasting at least four weeks are required. The randomized controlled SalT Reduction InterVEntion (STRIVE) trial was developed to investigate the metabolic, behavioral and health effects of four months of consuming gradually salt reduced bread alone or in combination with dietary counselling. This paper describes the rationale and methods of STRIVE. Aiming at 120 healthy families, participants were recruited in February 2018 from the Danish Capital Region and randomly allocated into: (A) Salt reduced bread; (B) Salt reduced bread and dietary counseling; (C) Standard bread. Participants were examined before the intervention and at four months follow-up. Primary outcome is change in salt intake measured by 24 h urine. Secondary outcomes are change in urine measures of potassium and sodium/ potassium ratio, blood pressure, plasma lipids, the renin-angiotensin system, the sympathetic nervous response, dietary intake as well as salt taste sensitivity and preferences. The results will qualify mechanisms affected during a gradual reduction in salt intake in compliance with the current public health recommendations.

AB - Reductions in salt intake have the potential to markedly improve population health at low cost. Real life interventions that explore the feasibility and health effects of a gradual salt reduction lasting at least four weeks are required. The randomized controlled SalT Reduction InterVEntion (STRIVE) trial was developed to investigate the metabolic, behavioral and health effects of four months of consuming gradually salt reduced bread alone or in combination with dietary counselling. This paper describes the rationale and methods of STRIVE. Aiming at 120 healthy families, participants were recruited in February 2018 from the Danish Capital Region and randomly allocated into: (A) Salt reduced bread; (B) Salt reduced bread and dietary counseling; (C) Standard bread. Participants were examined before the intervention and at four months follow-up. Primary outcome is change in salt intake measured by 24 h urine. Secondary outcomes are change in urine measures of potassium and sodium/ potassium ratio, blood pressure, plasma lipids, the renin-angiotensin system, the sympathetic nervous response, dietary intake as well as salt taste sensitivity and preferences. The results will qualify mechanisms affected during a gradual reduction in salt intake in compliance with the current public health recommendations.

KW - Cardiovascular consequences

KW - Gradual salt reduction

KW - Randomized controlled trial

KW - Sodium potassium ratio

KW - Statistical analysis plan

UR - http://www.scopus.com/inward/record.url?scp=85072677604&partnerID=8YFLogxK

U2 - 10.3390/ijerph16193532

DO - 10.3390/ijerph16193532

M3 - Journal article

VL - 16

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

SN - 1661-7827

IS - 19

M1 - 3532

ER -

ID: 58033179