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Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Salivary microbiota and inflammation-related proteins in patients with psoriasis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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OBJECTIVE: The purpose of the present study was to characterize the composition of the salivary microbiota and quantify salivary levels of inflammation-related proteins (neutrophil gelatinase-associated lipocalin [NGAL] and transferrin) in patients with psoriasis and compare data to those obtained in patients with periodontitis and orally healthy controls, respectively.

MATERIAL AND METHODS: Stimulated saliva samples from patients with psoriasis (n=27), patients with periodontitis (n=58) and orally healthy controls (n=52) were characterized by means of next generation sequencing of the 16S rRNA gene. Salivary levels of NGAL and transferrin were quantified using immunoassays.

RESULTS: Linear discriminant effect size analysis showed that 52 (22 psoriasis-associated, 30 periodontitis-associated) and 21 (8 psoriasis-associated, 13 orally healthy control-associated) bacterial taxa differentiated the salivary microbiota in patients with psoriasis from that of patients with periodontitis and orally healthy controls, respectively. Significantly lower mean salivary levels of NGAL (psoriasis: 996 [std. error 320], periodontitis: 2072 [295], orally healthy controls: 2551 [345] ng/ml, p<0.0001) and transferrin (psoriasis: 4.37 [0.92], periodontits: 7.25 [0.88], orally healthy controls: 10.02 [0.94] ng/ ml, p<0.0001) were identified in patients with psoriasis.

CONCLUSIONS: Psoriasis associates with characteristics of the salivary microbiota and salivary levels of inflammation-related proteins, which are different from characteristics in patients with periodontitis and orally healthy controls, respectively.

OriginalsprogEngelsk
TidsskriftOral Diseases
ISSN1354-523X
DOI
StatusE-pub ahead of print - 9 jan. 2020

Bibliografisk note

© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.

ID: 58981246