Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Salivary microbiota and inflammation-related proteins in patients with psoriasis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Prevalence, type distribution, and risk factors for oral HPV in Danish renal transplant recipients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Workshop of European task force on medication-related osteonecrosis of the jaw-Current challenges

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Time to onset of bisphosphonate-related osteonecrosis of the jaws: a multicentre retrospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Management of patients with ocular manifestations in vesiculobullous disorders affecting the mouth

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Effect of a local anesthetic lozenge in relief of symptoms in burning mouth syndrome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Alcohol septal ablation in patients with severe septal hypertrophy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Amyloid transthyretinkardiomyopati

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Systemic Treatment of Psoriasis with JAK Inhibitors: A Review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Cardiovascular and metabolic health effects of team handball training in overweight women: Impact of prior experience

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: The purpose of the present study was to characterize the composition of the salivary microbiota and quantify salivary levels of inflammation-related proteins (neutrophil gelatinase-associated lipocalin [NGAL] and transferrin) in patients with psoriasis and compare data to those obtained in patients with periodontitis and orally healthy controls, respectively.

MATERIALS AND METHODS: Stimulated saliva samples from patients with psoriasis (n = 27), patients with periodontitis (n = 58), and orally healthy controls (n = 52) were characterized by means of next-generation sequencing of the 16S rRNA gene. Salivary levels of NGAL and transferrin were quantified using immunoassays.

RESULTS: Linear discriminant effect size analysis showed that 52 (22 psoriasis-associated and 30 periodontitis-associated) and 21 (8 psoriasis-associated and 13 orally healthy control-associated) bacterial taxa differentiated the salivary microbiota in patients with psoriasis from that of patients with periodontitis and orally healthy controls, respectively. Significantly lower mean salivary levels of NGAL (psoriasis: 996 [std. error 320], periodontitis: 2,072 [295], orally healthy controls: 2,551 [345] ng/ml, p < .0001) and transferrin (psoriasis: 4.37 [0.92], periodontitis: 7.25 [0.88], orally healthy controls: 10.02 [0.94] ng/ml, p < .0001) were identified in patients with psoriasis.

CONCLUSIONS: Psoriasis associates with characteristics of the salivary microbiota and salivary levels of inflammation-related proteins, which are different from characteristics in patients with periodontitis and orally healthy controls, respectively.

OriginalsprogEngelsk
TidsskriftOral Diseases
ISSN1354-523X
DOI
StatusE-pub ahead of print - 9 jan. 2020

ID: 58981246