Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Safety of early ileostomy closure: a systematic review and meta-analysis of randomized controlled trials

Publikation: Bidrag til tidsskriftReviewpeer review

DOI

  1. Outcome following local excision of T1 anal cancers-a systematic review

    Publikation: Bidrag til tidsskriftReviewpeer review

  2. Treatment of chronic anal fissure: a feasibility study on Levorag® Emulgel versus Diltiazem gel 2

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The effect of gender on early colonic anastomotic wound healing

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The prognostic value of tumour stroma ratio and tumour budding in stage II colon cancer. A nationwide population-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Validation of the Danish Colorectal Cancer Group (DCCG.dk) database - on behalf of the Danish Colorectal Cancer Group

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Impact of long-term storage of plasma and cell-free DNA on measured DNA quantity and fetal fraction

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Outcome following local excision of T1 anal cancers-a systematic review

    Publikation: Bidrag til tidsskriftReviewpeer review

  4. Anastomotic technique is not associated with leakage rate after right hemicolectomy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. External quality assessment of noninvasive fetal RHD genotyping

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

PURPOSE: Patients with a defunctioning ileostomy after rectal resection experience substantial ileostomy-related morbidity and decreased quality of life. Early reversal of the defunctioning ileostomy has been proposed as a method of mitigating these problems. We aimed to evaluate the safety of early ileostomy closure within 6 weeks.

METHOD: Randomized controlled trials investigating the safety of early ileostomy closure were identified through a systematic search and review of the current literature. Meta-analysis of the extracted outcome data was performed, and the methodological quality of the individual studies was assessed.

RESULTS: The search identified six eligible studies yielding a total of 528 patients, with 269 in the early closure (EC) group and 259 in the standard closure (SC) group. Major complications in the EC group was 5.2% compared with 3.6% in the SC group (RR = 1.12, 95% CI 0.33-3.79). Anastomotic leakage in the EC group was 3.3% compared with 3.5% in the SC group (RR = 0.89, 95% CI 0.29-2.75). The meta-analysis resulted in no statistically significant differences between the groups in any of the primary or secondary outcomes.

CONCLUSION: This review was not able to discern a statistically significant difference in postoperative complications when comparing early and standard ileostomy closure. The current literature indicates that early ileostomy closure is not associated with higher complication rates in patients with an uncomplicated postoperative course and radiologically verified intact distal anastomosis after index surgery.

OriginalsprogEngelsk
TidsskriftInternational Journal of Colorectal Disease
Vol/bind36
Udgave nummer2
Sider (fra-til)203-212
Antal sider10
ISSN0179-1958
DOI
StatusUdgivet - feb. 2021

ID: 61811239