Rygestop i graviditeten, nyfødtes størrelse og NO-syntase-aktivitet i navlesnorens endotelceller--sekundaerpublikation

Malene R Andersen, Ulf Simonsen, Niels Uldbjerg, Christian Aalkjaer, Steen Stender

Abstract

Newborns of smokers had a lower weight, a smaller head circumference, and were shorter than newborns of smokers and ex-smokers, who stopped smoking early in pregnancy. The activity and concentration of the enzyme which produces the vasodilator nitric oxide were 36% and 47% lower, respectively, in endothelial cells of the umbilical vein from smokers compared with that from nonsmokers and ex-smokers. The findings suggest that smoking reduces nitric oxide production in the foetal vascular bed, contributing to retarded foetal growth caused by the reduction of vasodilatory capacity.

Bidragets oversatte titelSmoking cessation during pregnancy, newborn size, and NO-synthase activity in endothelial cells of the umbilical cord--secondary publication
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind171
Udgave nummer25
Sider (fra-til)2088-91
Antal sider4
ISSN0041-5782
StatusUdgivet - 15 jun. 2009

Emneord

  • Adult
  • Birth Weight
  • Body Height
  • Endothelium, Vascular/enzymology
  • Female
  • Head/growth & development
  • Humans
  • Infant, Newborn
  • Nitric Oxide Synthase Type III/metabolism
  • Pregnancy
  • Smoking Cessation
  • Umbilical Veins/enzymology
  • Vasodilation
  • Young Adult

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