Rygestop i graviditeten, nyfødtes størrelse og NO-syntase-aktivitet i navlesnorens endotelceller--sekundaerpublikation

Malene R Andersen; Ulf Simonsen; Niels Uldbjerg; Christian Aalkjaer; Steen Stender

Rygestop i graviditeten, nyfødtes størrelse og NO-syntase-aktivitet i navlesnorens endotelceller--sekundaerpublikation

Malene R Andersen, Ulf Simonsen, Niels Uldbjerg, Christian Aalkjaer, Steen Stender

Klinisk Biokemisk afd.

Abstract

Newborns of smokers had a lower weight, a smaller head circumference, and were shorter than newborns of smokers and ex-smokers, who stopped smoking early in pregnancy. The activity and concentration of the enzyme which produces the vasodilator nitric oxide were 36% and 47% lower, respectively, in endothelial cells of the umbilical vein from smokers compared with that from nonsmokers and ex-smokers. The findings suggest that smoking reduces nitric oxide production in the foetal vascular bed, contributing to retarded foetal growth caused by the reduction of vasodilatory capacity.

Bidragets oversatte titel	Smoking cessation during pregnancy, newborn size, and NO-synthase activity in endothelial cells of the umbilical cord--secondary publication
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	171
Udgave nummer	25
Sider (fra-til)	2088-91
Antal sider	4
ISSN	0041-5782
Status	Udgivet - 15 jun. 2009

Emneord

Adult
Birth Weight
Body Height
Endothelium, Vascular/enzymology
Female
Head/growth & development
Humans
Infant, Newborn
Nitric Oxide Synthase Type III/metabolism
Pregnancy
Smoking Cessation
Umbilical Veins/enzymology
Vasodilation
Young Adult

Citationsformater

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title = "Rygestop i graviditeten, nyf{\o}dtes st{\o}rrelse og NO-syntase-aktivitet i navlesnorens endotelceller--sekundaerpublikation",

abstract = "Newborns of smokers had a lower weight, a smaller head circumference, and were shorter than newborns of smokers and ex-smokers, who stopped smoking early in pregnancy. The activity and concentration of the enzyme which produces the vasodilator nitric oxide were 36% and 47% lower, respectively, in endothelial cells of the umbilical vein from smokers compared with that from nonsmokers and ex-smokers. The findings suggest that smoking reduces nitric oxide production in the foetal vascular bed, contributing to retarded foetal growth caused by the reduction of vasodilatory capacity.",

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author = "Andersen, {Malene R} and Ulf Simonsen and Niels Uldbjerg and Christian Aalkjaer and Steen Stender",

year = "2009",

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AU - Andersen, Malene R

AU - Simonsen, Ulf

AU - Uldbjerg, Niels

AU - Aalkjaer, Christian

AU - Stender, Steen

PY - 2009/6/15

Y1 - 2009/6/15

N2 - Newborns of smokers had a lower weight, a smaller head circumference, and were shorter than newborns of smokers and ex-smokers, who stopped smoking early in pregnancy. The activity and concentration of the enzyme which produces the vasodilator nitric oxide were 36% and 47% lower, respectively, in endothelial cells of the umbilical vein from smokers compared with that from nonsmokers and ex-smokers. The findings suggest that smoking reduces nitric oxide production in the foetal vascular bed, contributing to retarded foetal growth caused by the reduction of vasodilatory capacity.

AB - Newborns of smokers had a lower weight, a smaller head circumference, and were shorter than newborns of smokers and ex-smokers, who stopped smoking early in pregnancy. The activity and concentration of the enzyme which produces the vasodilator nitric oxide were 36% and 47% lower, respectively, in endothelial cells of the umbilical vein from smokers compared with that from nonsmokers and ex-smokers. The findings suggest that smoking reduces nitric oxide production in the foetal vascular bed, contributing to retarded foetal growth caused by the reduction of vasodilatory capacity.

KW - Adult

KW - Birth Weight

KW - Body Height

KW - Endothelium, Vascular/enzymology

KW - Female

KW - Head/growth & development

KW - Humans

KW - Infant, Newborn

KW - Nitric Oxide Synthase Type III/metabolism

KW - Pregnancy

KW - Smoking Cessation

KW - Umbilical Veins/enzymology

KW - Vasodilation

KW - Young Adult

M3 - Tidsskriftartikel

C2 - 19678433

SN - 0041-5782

VL - 171

SP - 2088

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JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

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ER -

Rygestop i graviditeten, nyfødtes størrelse og NO-syntase-aktivitet i navlesnorens endotelceller--sekundaerpublikation

Abstract

Emneord

Fingeraftryk

Citationsformater