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Udgivet

Runs of homozygosity and testicular cancer risk

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  • UK Testicular Cancer Collaboration
  • PRACTICAL consortium (Børge Nordestgaard)
  • Børge G. Nordestgaard (Medlem af forfattergruppering)
Vis graf over relationer

BACKGROUND: Testicular germ cell tumour (TGCT) is highly heritable but > 50% of the genetic risk remains unexplained. Epidemiological observation of greater relative risk to brothers of men with TGCT compared to sons has long alluded to recessively acting TGCT genetic susceptibility factors, but to date none have been reported. Runs of homozygosity (RoH) are a signature indicating underlying recessively acting alleles and have been associated with increased risk of other cancer types.

OBJECTIVE: To examine whether RoH are associated with TGCT risk.

METHODS: We performed a genome-wide RoH analysis using GWAS data from 3206 TGCT cases and 7422 controls uniformly genotyped using the OncoArray platform.

RESULTS: Global measures of homozygosity were not significantly different between cases and controls, and the frequency of individual consensus RoH was not significantly different between cases and controls, after correction for multiple testing. RoH at three regions, 11p13-11p14.3, 5q14.1-5q22.3 and 13q14.11-13q.14.13, were, however, nominally statistically significant at p < 0.01. Intriguingly, RoH200 at 11p13-11p14.3 encompasses Wilms tumour 1 (WT1), a recognized cancer susceptibility gene with roles in sex determination and developmental transcriptional regulation, processes repeatedly implicated in TGCT aetiology.

DISCUSSION AND CONCLUSION: Overall, our data do not support a major role in the risk of TGCT for recessively acting alleles acting through homozygosity, as measured by RoH in outbred populations of cases and controls.

OriginalsprogEngelsk
TidsskriftAndrology
Vol/bind7
Udgave nummer4
Sider (fra-til)555-564
Antal sider10
ISSN2047-2919
DOI
StatusUdgivet - jul. 2019

Bibliografisk note

© 2019 American Society of Andrology and European Academy of Andrology.

ID: 59309672